A Creighton University School of Medicine researcher has been awarded a $2.7 million grant by the National Institutes of Health (NIH) to investigate a possible link between the ingestion of tortillas and corn-based food products contaminated with a fungal toxin and increased risk for birth defects.
The three-year award is a collaborative effort among investigators at Creighton, the U.S. Department of Agriculture-Agricultural Research Service (USDA-ARS) in Athens, Georgia; Duke University Medical Center in Durham, N.C., and Centro de Investigaciones en Nutricion y Salud (CIENSA) in Guatemala.
Janee Gelineau-van Waes, D.V.M., Ph.D., principal investigator and associate professor in Creighton’s Department of Pharmacology, will use the grant to continue her research studying a potential connection between exposure to fumonisin during early pregnancy and an increased risk for having a baby with a neural tube defect (NTD).
A team of researchers, led by Ashley Moffett, at the University of Cambridge, United Kingdom, has shed new light on genetic factors that increase susceptibility to and provide protection from common disorders of pregnancy, specifically recurrent miscarriage, preeclampsia, and fetal growth restriction.
A key step in the initiation of a successful pregnancy is the invasion of the lining of the uterus by fetal cells known as trophoblasts, which become the main cell type of the placenta. Recurrent miscarriage, preeclampsia, and fetal growth restriction are thought to result from inadequate trophoblast invasion of the uterus lining. Interactions between maternal cells known as uterine NK cells and fetal trophoblasts — specifically interactions between HLA-C molecules on the fetal trophoblasts and KIRs on the maternal uterine NK cells — are key to determining the extent of trophoblast invasion. Previous data from Moffett’s lab indicated that a particular combination of fetal HLA-C and maternal KIR was associated with increased risk of preeclampsia. In this study, the team has extended this correlation to recurrent miscarriage and fetal growth restriction. Furthermore, they have determined that the presence of other maternal KIRs that combine with the same HLA-C molecule provides protection against the same common disorders of pregnancy.
Fitness loves company, whether it’s a running buddy, a spotter in the weight room, or a pal to bolster your courage as you tackle that first yoga class.
Experts say buddying up can make your workout easier to stick with and harder to miss.
“People don’t necessarily work out for social reasons, but that social factor can keep them working out,” said Kerri O’Brien of Life Fitness, the equipment manufacturer.
They are one of the most highly prized delicacies in the culinary world, but now scientists have discovered that black truffles are locked in a gender war for reproduction. The research, published in New Phytologist as the truffle season begins, represents a breakthrough in the understanding of truffle cultivation and distribution.
The teams, led by Dr Francesco Paolocci and Dr Andrea Rubini from the CNR Plant Genetics Institute in Perugia and by Dr Francis Martin from INRA in Nancy, carried out their research on the reproduction strategy of the highly prized black truffle, Tuber melanosporum, which is grown across southern Europe. During the truffle season, between late autumn and winter, fruiting truffles can grow up to 7cm in diameter, weighing up to 100g with a value often measured in hundreds of Euros.
‘Fruiting’ is the crucial part of the truffle life cycle, occurring when the fungi interacts with and colonises host plants, usually at the roots. However, the process which causes this transition from vegetative to reproductive state remains unknown.
Clutching her sickly 1-1/2-year-old son, Anna Langella says the family doctor had this simple prescription for her: move somewhere else.
Langella says her toddler often vomits and she blames this on the foul smell and toxic waste piling up in a rubbish dump near her house in Terzigno, on the outskirts of Naples where the streets are strewn with mounds of garbage.
“We have to keep the children inside, with the doors and windows shut, but even then it’s not enough,” she told Reuters. “It’s terrible. The state has abandoned us.”