A team of scientists has developed a way to coax tumor cells in the lab to grow into 3-D spheres. Their discovery takes advantage of an earlier technique of producing spherical cavities in a common polymer and promises more accurate tests of new cancer therapies.
As team leader Michael R. King, Ph.D., of Cornell University explains, “Sometimes engineering research tends to be a case of a hammer looking for a nail. We knew our previous discovery was new and it was cool. And now we know it’s useful.”
Three years ago, the team—in collaboration with Lisa DeLouise, Ph.D., MPD, of Rochester, N.Y.—perfected a low-cost, easy fabrication technique to make spherical cavities in PDMS (polydimethylsiloxane), a widely used silicon organic polymer. More recently, the Cornell team discovered that these cavities could be used as a scaffolding to grow numerous tumor spheroids, which could serve as realistic models for cancer cells. The Cornell team’s work appears in the current issue of Biomicrofluidics, a publication of the American Institute of Physics.