Histochemistry is the golden standard in the diagnosis of carcinosarcomas
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A case study of carcinosarcoma has been published in the World Journal of Gastroenterology on November 7, 2007. The patient in the study was the first case of gastric carcinosarcoma obtained in this part of the world . The patient was admitted by Dr. Tomislav Randjelovic as surgeon and Dr. Branka Filipovic as gastroenterologist. The operation was performed by Dr. Randjelovic and his team; the anatomical and patoanatomical evaluation of macroscopic and microscopic features of the tumor were performed by Dr. Babic, Dr. Cemerikic and Dr. Filipovic.
Carcinosarcomas are very rare malignancies in the Western Balkans.
Moreover, our case is, to the best of our knowledge, the first ever reported . It is important never to reject the possibility of the appearance of carcinosarcoma in differential diagnosis of the clinical manifestations described in our paper, which appeared to be unspecific and could potentially be connected with numerous diseases of the stomach.
Their case shows that histochemistry is the golden standard in the diagnosis of carcinosarcomas: epithelial component expressed positivity for cytokeratin 18, epithelial membranous antigen (EMA), and carcinoembryonic antigen (CEA). Chromogranin A positive epithelial cells could also be observed. The mesenchymal component had intensive staining for vimentin, although neither muscular nor neural differentiation could be found. No Helicobacter pylori was seen.
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World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection for providing a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2003-2000 IF: 3.318, 2.532, 1.445 and 0.993. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. The WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.
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