Beta-adrenergic Blocking Agents and Thiazide Diuretics (Systemic)

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common

Breathing difficulty and/or wheezing; cold hands and feet; mental depression; slow heartbeat (especially less than 50 beats per minute); swelling of ankles, feet, and/or lower legs

Rare

Black, tarry stools; blood in urine or stools; chest pain; dark urine; fever, chills, cough, or sore throat; hallucinations (seeing, hearing, or feeling things that are not there); joint pain; lower back or side pain; pinpoint red spots on skin; red, scaling, or crusted skin; skin rash or hives; stomach pain (severe) with nausea and vomiting; unusual bleeding or bruising; or yellow eyes or skin

Signs and symptoms of too much potassium or sodium loss

Confusion; convulsions (seizures); dryness of mouth; increased thirst; irregular heartbeats; irritability, mood or mental changes; muscle cramps or pain; nausea or vomiting, unusual tiredness or weakness; weak pulse

Signs and symptoms of overdose (in the order in which they may occur)

Slow heartbeat; dizziness (severe) or fainting; difficulty in breathing; bluish-colored fingernails or palms of hands; convulsions (seizures)

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

More common

Decreased sexual ability; dizziness or lightheadedness; drowsiness (mild); trouble in sleeping

Less common

Anxiety or nervousness; constipation; diarrhea; increased sensitivity of skin to sunlight (skin rash, itching, redness or other discoloration of skin, or severe sunburn); loss of appetite; numbness or tingling of fingers and toes; stomach discomfort or upset; stuffy nose

Rare

Changes in taste; dry, sore eyes; itching of skin; nightmares and vivid dreams

Although not all of the above side effects have been reported for all of these medicines, they have been reported for at least one of the beta-blockers or thiazide diuretics. Since all of the beta-blockers are very similar and the thiazide diuretics are also very similar, any of the above side effects may occur with any of these medicines. However, they may be more common with some combinations than with others.

After you have been taking this medicine for a while, it may cause unpleasant or even harmful effects if you stop taking it too suddenly. After you stop taking this medicine or while you are gradually reducing the amount you are taking, check with your doctor right away if any of the following occur:

Chest pain; fast or irregular heartbeat; general feeling of discomfort, illness, or weakness; headache; shortness of breath (sudden); sweating; trembling

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.