Bortezomib (Systemic)

Brand Names : Velcade

Proper Use of This Medicine

Dosing - The dose of bortezomib will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of bortezomib. If you have any questions about the proper dose of bortezomib, ask your doctor.

• For injection dosage form
  • For treatment of multiple myeloma
    • Adults -
      • Patients without symptoms or with Grade 1 symptoms of peripheral neuropathy (paresthesias and/or loss of reflexes without pain or loss of function) - 1.3 milligrams (mg) per m² twice weekly for two weeks (days 1, 4, 8, and 11) followed by a 10-day rest period (days 12-21). At least 72 hours should elapse between consecutive dose.
      • Patients with Grade 1 with pain or Grade 2 symptoms of peripheral neuropathy (interfering with function but not with activities of daily living) - 1 milligram (mg) per m² twice weekly for two weeks (days 1, 4, 8, and 11) followed by a 10-day rest period (days 12-21). At least 72 hours should elapse between consecutive dose.
      • Patients with Grade 2 with pain or Grade 3 symptoms of peripheral neuropathy (interfering with activities of daily living) - Your doctor will withhold therapy until toxicity resolves. When toxicity resolves your doctor will reduce your dose to 0.7 mg/m² once per week.
      • Patients with Grade 4 symptoms of peripheral neuropathy (permanent sensory loss that interferes with function) - Your doctor will discontinue therapy
    • Children - Bortezomib is not usually recommended in children.

Missed dose - Discuss with your doctor what to do