Gonadorelin (Systemic)
Brand Names : Factrel, Lutrepulse, Relisorm, luteinizing hormone–releasing hormone, luteinizing hormone–releasing factor dihydrochloride, luteinizing hormone–releasing factor diacetate tetrahydrate, luteinizing hormone–/follicle-stimulating hormone–releasing hormone
Proper Use of This MedicineIf you are
having a test done with gonadorelin, one or more samples of your blood will
be taken. Then gonadorelin is given by an intravenous (into a vein) or a subcutaneous
(under the skin) injection. At regular times after the medicine is given,
more blood samples will be taken. Then the results of the test will be studied.
Some medicines given by injection or by injection pump may sometimes be
given at home to patients who do not need to be in the hospital. If you are
using this medicine at home, make sure you clearly understand
and carefully follow your doctor's instructions
.
For Lutrepulse
pump - The Lutrepulse
pump is a device containing
gonadorelin. It automatically injects the medicine into a vein. The pump will
be attached to a belt that is placed around your waist. Tubing from the pump
will be taped to your chest, shoulder, and arm, as the tubing goes up your
chest to your shoulder and then comes down your arm. A needle will be attached
to the end of the tubing. It is inserted into a vein on the inner part of
the crook of your elbow. A dressing is used to keep the needle protected.
You will need to know how to take care of the equipment
and the injection site
.
To care for the pump:
-
When showering or bathing, remove the belt with the device from your
abdomen and any tape attached to your stomach and chest without removing the
tape, tubing, or needle from your arm. The device is not water-proof. You
will need to hang it outside on the railing of the shower and carefully shower
without pulling the needle and tubing from your arm.
-
When getting into bed, you must also remove the device from the abdomen
as stated above, without removing the tape, tubing, or needle from your arm.
Place the device above your pillow, then pin it to your bedsheets so that
it does not fall off the bed. This will give you freedom of movement while
sleeping.
-
Know the warning signals that your pump can produce to alert you
to problems, such as low battery, among other messages. Do not try to take the pump apart yourself. Call your health care professional
for directions if warning signals sound
.
To care for the injection site:
-
Inspect the injection site daily. Report to doctor
if the skin at the injection site becomes red or swollen, if you experience
fever or chills, if the needle comes out of your arm, if blood is seen in
the tubing, or if the tubing becomes disconnected from the pump
.
-
Keep the protective dressing in place over the needle, replacing
it if it gets wet or dirty.
-
Avoid putting pressure on the needle placed in your arm.
-
Carefully keep the tubing taped to your skin to keep it securely
in place and to prevent it from kinking.
-
The needle should be replaced every 48 hours.
Dosing - The dose of gonadorelin will be different for
different patients. Follow your doctor's orders
.
The following information includes only the average doses of gonadorelin.
-
For injection
dosage form (for Lutrepulse
pump):
-
For treating amenorrhea or infertility in women caused by pituitary
or hypothalamus problems:
-
Adults - 5 microgram (mcg) injected by the pump into a vein or
under the skin slowly over 1 minute, every ninety minutes for twenty-one days.
As determined by doctor, dose may be changed slowly, decreased to 1 mcg or
increased to 20 mcg if needed.
-
Children up to 18 years of age - Use and dose must be determined
by the doctor.
-
For injection
dosage form (single-dose
injection):
-
For testing the hypothalamus and pituitary glands:
-
Adults - 0.1 milligram (mg) injected once as a single dose under
the skin or into a vein.
-
Children 12 years of age and older - 2 micrograms (mcg) per kilogram
(kg) (0.9 mcg per pound) of body weight, not to exceed a single dose of 100
mcg, injected once under the skin or into vein.
-
Children up to 12 years of age - Use and dose must be determined
by doctor.
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