Oxtriphylline and Guaifenesin (Systemic)
Brand Names : Brondelate, Choledyl Expectorant
Before Using This MedicineIn deciding to use a medicine,
the risks of taking the medicine must be weighed against the good it will
do. This is a decision you and your doctor will make. For oxtriphylline and
guaifenesin combination, the following should be considered:
Allergies - Tell your doctor if you have ever had any unusual or
allergic reaction to aminophylline, guaifenesin, oxtriphylline, or theophylline.
Diet - Make certain your health care professional
knows if you are on any special diet, such as a high-protein, low-carbohydrate
or low-protein, high-carbohydrate diet.
Pregnancy - Oxtriphylline is used to treat asthma in pregnant
women. Although there are no studies on birth defects in humans, problems
have not been reported. Some studies in animals have shown that oxtriphylline
can cause birth defects when given in doses many times the human dose. Because your ability to clear oxtriphylline from your body may decrease
later in pregnancy, your doctor may want to take blood samples during your
pregnancy to measure the amount of medicine in the blood. This will help your
doctor decide whether the dose of this medicine should be changed.
Oxtriphylline crosses the placenta. Use of this medicine during pregnancy
may cause unwanted effects such as fast heartbeat, irritability, jitteriness,
or vomiting in the newborn infant if the amount of medicine in your blood
is too high.
Several groups of women taking guaifenesin during pregnancy have been studied.
In one group, when guaifenesin was taken during the first 3 months of pregnancy,
the babies had more inguinal hernias than expected. However, more birth defects
than expected did not occur in the babies of other groups of women taking
guaifenesin during pregnancy. Studies with guaifenesin have not been done
in animals.
Breast-feeding - Theophylline passes into the breast milk and may
cause irritability in nursing babies. Guaifenesin has not been reported to
cause problems in nursing babies.
Children - Use of this medicine is not recommended because of
high alcohol content. Although there is no specific information about the use of guaifenesin
in children, it is not expected to cause different side effects or problems
in children than it does in adults.
Older adults - Patients older than 60 years of age are likely to
require a lower dose than younger adults. If the amount of oxtriphylline is
too high, side effects are more likely to occur. Your doctor may want to take
blood samples to determine whether a dose change is needed. Although there is no specific information about the use of guaifenesin
in the elderly, it is not expected to cause different side effects or problems
in older people than it does in younger adults.
Other medicines - Although certain medicines should not be used
together at all, in other cases two different medicines may be used together
even if an interaction might occur. In these cases, your doctor may want to
change the dose, or other precautions may be necessary. When you are taking
oxtriphylline and guaifenesin combination, it is especially important that
your health care professional know if you are taking any of the following:
-
Beta-adrenergic blocking agents including those used in the eyes
(acebutolol [e.g., Sectral], atenolol [e.g., Tenormin], betaxolol [e.g., Betoptic,
Kerlone], bisoprolol [e.g., Zebeta], carteolol [e.g., Cartrol], labetalol
[e.g., Normodyne], levobunolol [e.g., Betagan], metipranolol [e.g., OptiPranolol],
metoprolol [e.g., Lopressor], nadolol [e.g., Corgard], oxprenolol [e.g., Trasicor],
penbutolol [e.g., Levatol], pindolol [e.g., Visken], propranolol [e.g., Inderal],
sotalol [e.g., Sotacor], timolol [e.g., Blocadren, Timoptic]) - These
medicines may prevent oxtriphylline from working properly
-
Cimetidine (e.g., Tagamet) or
-
Ciprofloxacin (e.g., Cipro) or
-
Clarithromycin (e.g., Biaxin) or
-
Enoxacin (e.g., Penetrex) or
-
Erythromycin (e.g., E-Mycin) or
-
Fluvoxamine (e.g., Luvox) or
-
Mexiletine (e.g., Mexitil) or
-
Pentoxifylline (e.g., Trental) or
-
Tacrine (e.g., Cognex) or
-
Thiabendazole or
-
Ticlopidine (e.g., Ticlid) or
-
Troleandomycin (e.g., TAO) - These medicines may increase the
effects of oxtriphylline
-
Moricizine (e.g., Ethmozine) or
-
Phenytoin (e.g., Dilantin) or
-
Rifampin (e.g., Rifadin) - These medicines may decrease the effects
of oxtriphylline
-
Smoking tobacco or marijuana - Starting or stopping smoking may
change the effectiveness of this medicine
Other medical problems - The presence of other medical
problems may affect the use of oxtriphylline and guaifenesin combination.
Make sure you tell your doctor if you have any other medical problems, especially:
-
Convulsions (seizures) - Oxtriphylline may make this condition
worse
-
Heart failure or
-
Liver disease or
-
Underactive thyroid - The effects of oxtriphylline may be increased
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