Procainamide (Systemic)

Brand Names : Procan SR, Promine, Pronestyl, Pronestyl-SR

Proper Use of This Medicine

Take procainamide exactly as directed by your doctor , even though you may feel well. Do not take more medicine than ordered.

Procainamide should be taken with a glass of water on an empty stomach 1 hour before or 2 hours after meals so that it will be absorbed more quickly. However, to lessen stomach upset, your doctor may want you to take the medicine with food or milk.

For patients taking the extended-release tablets :

• Swallow the tablet whole without breaking, crushing, or chewing it.

This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times day and night . For example, if you are to take 6 doses a day, the doses should be spaced about 4 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your health care professional.

Dosing - The dose of procainamide will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of procainamide. If your dose is different, do not change it unless your doctor tells you to do so.

The number of capsules or tablets that you take depends on the strength of the medicine.

• For regular (short-acting) oral dosage forms (capsules or tablets):
  • For atrial arrhythmias (fast or irregular heartbeat):
    • Adults - 500 milligrams (mg) to 1000 mg (1 gram) every four to six hours.
    • Children - 12.5 mg per kilogram (5.68 mg per pound) of body weight four times a day.
  • For ventricular arrhythmias (fast or irregular heartbeat):
    • Adults - 50 mg per kilogram (22.73 mg per pound) of body weight per day divided into eight doses taken every three hours.
    • Children - 12.5 mg per kilogram (5.68 mg per pound) of body weight four times a day.
• For long-acting oral dosage form (extended-release tablets):
  • For atrial arrhythmias (fast or irregular heartbeat):
    • Adults - 1000 mg (1 gram) every six hours.
    • Children - Use is not recommended.
  • For ventricular arrhythmias (fast or irregular heartbeat):
    • Adults - 50 mg per kilogram (22.73 mg per pound) of body weight per day divided into four doses taken every six hours.
• For injection dosage form:
  • For arrhythmias (fast or irregular heartbeat):
    • Adults -
      • First few doses : May be given intramuscularly (into the muscle) at 50 mg per kilogram (22.73 mg per pound) of body weight per day in divided doses every three hours; or may be given intravenously (into the vein) by slowly injecting 100 mg (mixed in fluid) every five minutes or infusing 500 to 600 mg (mixed in fluid) over a twenty-five to thirty minute period.
      • Doses after the first few doses : 2 to 6 mg (mixed in fluid) per minute infused into the vein.
    • Children - Dose must be determined by your doctor.

Missed dose - If you miss a dose of this medicine and remember within 2 hours (4 hours if you are taking the long-acting tablets), take it as soon as possible. However, if you do not remember until later, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage - To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store in the bathroom, refrigerator, near the kitchen sink, or in other damp places. Moisture usually present in these areas may cause the medicine to break down. Keep the container tightly closed and store in a dry place.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.