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You are here : 3-RX.com > Drugs & Medications > Quick Drug Information (DrugNotes) > Chlorpheniramine (Oral)

Chlorpheniramine (By Mouth)

Chlorpheniramine (klor-fen-IR-a-meen)

Treats hay fever and other types of allergies. Belongs to a class of drugs called antihistamines.

Brand Name(s):

C.P.M. Tablets, Chlorphen, Chlor-Phen, Chlor-Trimeton Allergy, Aller-Chlor, Teldrin HBP, Diabetic Tussin Allergy Relief
There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have ever had an allergic-type reaction to any antihistamine such as chlorpheniramine, or to brompheniramine, dexchlorpheniramine, or triprolidine. Do not give the 8 or 12 hour allergy tablets to children under 12 years of age, or the 4 hour tablet to children under 6 years of age unless your doctor tells you to.

How to Use This Medicine:

Liquid, Tablet, Long Acting Tablet, Chewable Tablet

  • Your doctor will tell you how much medicine to take and how often.
  • You may take your medicine with food or milk to avoid stomach upset. Drink plenty of fluids while taking this medicine.
  • Do not chew or crush the extended-release tablet.

If a dose is missed:

  • Take your medicine as soon as you remember that you have missed your dose.
  • If it is nearly time for your next dose, wait until then to take the medicine and skip the missed dose.
  • You should not use two doses at one time.
How to Store and Dispose of This Medicine:

  • Store the medicine at room temperature, away from heat, direct light, and moisture. Do not freeze the oral liquid.
  • Keep all medicine away from children.
Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are taking monoamine oxidase (MAO) inhibitor-type medicines such as isocarboxazid (Marplan®), phenelzine (Nardil), or Eldepryl®.
  • Avoid drinking alcohol while taking this medicine.
  • Avoid taking medicines such as sleeping pills, tranquilizers, sedatives, narcotic pain killers, or antidepressants while you are taking chlorpheniramine.
Warnings While Using This Medicine:

  • Talk to your doctor before taking this medicine if you are pregnant or breastfeeding, or if you have glaucoma, a kidney disease, enlarged prostate, asthma, or stomach ulcer.
  • Check with your doctor if you will be having surgery and general anesthesia within 2 months of taking chlorpheniramine.
  • This medicine may make you drowsy or dizzy. Be careful when driving or using machinery.
Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Severe drowsiness
  • Unexplained high fever with sore throat
  • Hallucinations
  • Shortness of breath or trouble breathing
  • Trouble urinating - less than 1 cup (8 ounces) of urine in one day

If you notice these less serious side effects, talk with your doctor:

  • Drowsiness
  • Dry mouth
  • Clumsiness
  • Thick mucus
  • Nervousness
  • Upset stomach
If you notice other side effects that you think are caused by this medicine, tell your doctor.


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