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You are here : 3-RX.com > Drugs & Medications > Quick Drug Information (DrugNotes) > Erythromycin/Benzoyl Peroxide (Topical)

Erythromycin/Benzoyl Peroxide (On The Skin)

Benzoyl Peroxide (BEN-zoe-ill per-OX-ide), Erythromycin (er-ith-roe-MYE-sin)

Used on the skin to treat acne.

Brand Name(s):

Benzamycin, Benzamycin Pak
There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to erythromycin or benzoyl peroxide in the past.

How to Use This Medicine:


  • Your doctor will tell you how often to use this medicine.
  • For use on the skin only.
  • Wash and dry the area before you put on the medicine. If you have just shaved, you should wait 30 minutes before applying the medicine to prevent stinging or irritation.
  • Put the medicine on with your fingers and spread it over the affected area (on and around the acne).
  • Do not apply in or around the eyes.
  • Wash your hands after using.

If a dose is missed:

  • Apply the missed dose as soon as possible.
  • Skip the missed dose if it is almost time for your next regular dose.
  • You should not use twice as much medicine at one time.
How to Store and Dispose of This Medicine:

  • Store this medicine in the refrigerator, away from heat and direct light. Do not freeze.
  • Keep all medicine out of the reach of children.
Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Check with your doctor before using any other acne medicine on your skin.
  • Using PABA sunscreen and benzoyl peroxide together may cause your skin to change color. Ask your pharmacist for a sunscreen product that does not contain PABA.
Warnings While Using This Medicine:

  • If you are pregnant or breastfeeding, talk to your doctor before using this medicine.
  • Benzoyl peroxide may bleach hair and dyed fabric. Avoid getting the medicine on your hair or clothes.
Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Severe skin swelling or blistering

If you notice these less serious side effects, talk with your doctor:

  • Skin rash, redness, swelling or itching
  • Dry or peeling skin
  • Tenderness, stinging or burning
  • Eye irritation
If you notice other side effects that you think are caused by this medicine, tell your doctor.

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