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You are here : 3-RX.com > Drugs & Medications > Quick Drug Information (DrugNotes) > Propoxyphene/Aspirin/Caffeine (Oral)

Propoxyphene/Aspirin/Caffeine (By Mouth)

Aspirin (AS-pir-in), Caffeine (kaf-EEN), Propoxyphene Hydrochloride (proe-POX-i-feen hye-droe-KLOR-ide)

Treats various types of pain. Propoxyphene belongs to a class of drugs called narcotic analgesics.

Brand Name(s):

Darvon Compound 32, Darvon Compound-65, PC-Cap
There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you are allergic to propoxyphene, aspirin, or caffeine. Medicines that contain aspirin should not be taken by people with active ulcers, bleeding problems, or children or teenagers with symptoms of the flu or a viral infection.

How to Use This Medicine:


  • Your doctor will tell you how much to take and how often.
  • May be taken with food to lessen stomach upset.
  • Drink plenty of fluids to help avoid constipation.

If a dose is missed:

  • Take the missed dose as soon as possible.
  • Skip the missed dose if it is almost time for your next dose.
  • You should not use two doses at the same time.
How to Store and Dispose of This Medicine:

  • Store at room temperature, away from heat and moisture.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children.
Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Avoid drinking alcohol while taking this medicine.
  • Make sure your doctor knows if you are also taking blood thinners such as Coumadin®, medicine for gout, or any medicines that could make you drowsy such as sedatives, sleeping pills, or muscle relaxants.
Warnings While Using This Medicine:

  • This medicine can be habit-forming. You should not use more than your doctor ordered.
  • If you are pregnant or breastfeeding, talk with your doctor before taking this medicine.
  • Check with your doctor before taking if you have kidney or liver problems, or if you have a history of depression.
  • If you have taken this medicine for several weeks, ask your doctor before stopping. You may need to take smaller and smaller doses before stopping completely.
  • This medicine may make you drowsy or dizzy. Be careful if driving a car or using machinery.
Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Fast or slow heartbeat
  • Trouble breathing
  • Hives, skin rash, itching
  • Severe confusion or tiredness
  • Yellow skin or eyes

If you notice these less serious side effects, talk with your doctor:

  • Drowsiness, dizziness, or weakness
  • Dry mouth, nausea or vomiting
  • Constipation
  • Headache or blurred vision
If you notice other side effects that you think are caused by this medicine, tell your doctor.

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