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You are here : 3-RX.com > Drugs & Medications > Quick Drug Information (DrugNotes) > Thiethylperazine Maleate (Oral)

Thiethylperazine Maleate (By Mouth)

Thiethylperazine Maleate (thye-eth-il-PER-a-zeen MAL-ee-ate)

Treats nausea and vomiting. Belongs to a class of drugs called phenothiazines.

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to thiethylperazine or to related medicine, such as promethazine (Phenergan®) or prochlorperazine (Compazine®). You should not use thiethylperazine if you are pregnant or may become pregnant.

How to Use This Medicine:


  • Take this medicine exactly as your doctor ordered.
  • May be taken with or without food or milk.

If a dose is missed:

  • Take the missed dose as soon as you remember.
  • Skip the missed dose if it is almost time for your next regular dose.
  • You should not use two doses at the same time.
How to Store and Dispose of This Medicine:

  • Store at room temperature, away from heat, moisture, and direct light.
  • Keep all medicine out of the reach of children.
Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not drink alcohol while taking this medicine
  • Make sure your doctor knows if you are taking any medicine that can make you sleepy, such as sleeping pills, sedatives, tranquilizers, strong pain pills, or some cold and allergy medicines,
Warnings While Using This Medicine:

  • Check with your doctor before taking if you have heart, lung, blood, liver, or Parkinson's disease, asthma, glaucoma, enlarged prostate, trouble urinating, seizures, or drug or alcohol abuse problems.
  • Talk with your doctor before use if you are pregnant or breastfeeding.
  • Thiethylperazine can make some people dizzy or drowsy, be careful if you drive a car or operate machinery.
  • Standing up slowly from a sitting or lying position can lessen the chance of getting dizzy.
  • There is a risk of side effects with this medicine that include muscle spasms, twitching in the face or body, and uncontrolled tongue and jaw movement. Talk to your doctor about this risk.
Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Rapid or irregular heartbeat
  • Skin rash, severe itching or hives
  • Uncontrolled body movements
  • Uncontrolled chewing or tongue movements
  • Severe muscle stiffness or slurred speech
  • Fever, chills, or sore throat
  • Yellow skin or eyes
  • Mental confusion or seizures

If you notice these less serious side effects, talk with your doctor:

  • Drowsiness, dizziness, or restlessness
  • Headache
  • Dry mouth, nose or throat or poor appetite
  • Constipation or stomach cramps
  • Blurred vision
If you notice other side effects that you think are caused by this medicine, tell your doctor.

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