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Description
Clindamycin is an antiparasitic drug used in combination with pyrimethamine for maintenance treatment of toxoplasmosis. Clindamycin is used to treat acute toxoplasmosis, although it may not be as effective as pyrimethamine-sulfa. Clindamycin is also used as an experimental treatment for active PCP pneumonia. Clindamycin is used for treatment of skin infections, respiratory tract infections, septicemia, abdominal infections, gynecologic infections, and topical treatment of severe acne.

Side effects
Clindamycin may cause nausea, vomiting, diarrhea and mild rash. IV administration can cause a bitter taste in the mouth.

Dosage
Clindamycin comes in oral, injection and ointment formulations. The drug does not significantly cross the blood-brain barrier, but it crosses the placenta and enters breast milk. Clindamycin is mostly processed in the liver, so it should not be prescribed if you have liver impairment. Safety of the drug in pregnant or breast feeding women is not established. By mouth, adults are prescribed 150-450 mg every 6 hours. Pills must be taken with meals. Oral solution should not be refrigerated and is stable for 14 days at room temperature. Shake liquid preparations well. You must finish the drug as directed, even if you are feeling better. IV clindamycin is given 300-600 mg every 6-8 hours. Greater than 600 mg is not recommended. Topical clindamycin is applied in a 1% solution twice daily. The solution is flammable, so do not apply while smoking or near heat or flame. Wait 30 minutes after washing or shaving before applying.

How long it may take to work
Improvement should be seen in 2-3 weeks, but may take 8-12 weeks for maximum benefit. If you have toxoplasmosis, long term suppressive therapy is necessary. Improvement when used as treatment for PCP should be seen in 10 days.

Managing side effects
Notify your doctor immediately if diarrhea, abdominal cramping, fever, or bloody stools occur, and do not treat with antidiarrheals without your doctori's approval.

Storage?
To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store the capsule form of this medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not refrigerate the oral liquid form of clindamycin. If chilled, the liquid may thicken and be difficult to pour. Follow the directions on the label.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

It is important that your doctor check your progress at regular visits.

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

In some patients, clindamycin may cause diarrhea.

• Severe diarrhea may be a sign of a serious side effect. Do not take any diarrhea medicine without first checking with your doctor . Diarrhea medicines, such as loperamide (Imodium A-D) or diphenoxylate and atropine (Lomotil), may make your diarrhea worse or make it last longer.
• For mild diarrhea, diarrhea medicine containing attapulgite (e.g., Kaopectate tablets, Diasorb) may be taken. However, attapulgite may keep clindamycin from being absorbed into the body.
  Therefore, these diarrhea medicines should be taken at least 2 hours before or 3 to 4 hours after you take clindamycin by mouth.
• If you have any questions about this or if mild diarrhea continues or gets worse, check with your health care professional.

Before having surgery (including dental surgery) with a general anesthetic, tell the medical doctor or dentist in charge that you are taking clindamycin.

For more information check :

Cleocin T Gel (Clindamycin ) (Topical)


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