Alosetron (Systemic)

Brand Names : Lotronex

Proper Use of This Medicine

Read the Medication Guide before starting alosetron for the first time and each time you refill your alosetron prescription.

Your doctor will ask you to sign a Patient-Physician Agreement after you have read the Medication Guide for the first time. Signing the agreement means that you understand the risks and benefits of alosetron therapy and that you have read and understand the Medication Guide.

Do not start taking alosetron if you are constipated.

This medicine may be taken with or without food.

If constipation develops while your are taking alosetron, stop taking alosetron and check with your doctor.

Dosing - The dose of alosetron may be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of alosetron. If your dose is different, do not change it unless your doctor tells you to do so.

The number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking alosetron.

• For oral dosage form (tablets):
  • For irritable bowel syndrome associated with diarrhea:
    • Adults - 1 milligram (mg) once daily for 4 weeks to see how alosetron affects you. Your doctor will decide if you should continue to take alosetron and how much you should take.
    • Children - Use and dose must be determined by your doctor.

Missed dose - If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage - To store this medicine:

• Keep out of the reach of children.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Keep the medicine from freezing. Do not refrigerate.
• Do not keep outdated medicine or medicine no longer needed. Ask your health care professional how you should dispose of any medicine you do not use. Be sure that any discarded medicine is out of the reach of children.