Androgens and Estrogens (Systemic)
Side Effects of This Medicine
Discuss these possible effects
with your doctor:
Tumors of the liver, liver cancer, and peliosis hepatis (a form of
liver disease) have occurred during long-term, high-dose therapy with androgens.
Although these effects are rare, they can be very serious and may cause death.
When androgens are used in women, especially in high doses, male-like
changes may occur, such as hoarseness or deepening of the voice, unnatural
hair growth, or unusual hair loss. Most of these changes will go away if the
medicine is stopped as soon as the changes are noticed. However, some changes,
such as voice changes, may not go away.
The prolonged use of estrogens has been reported to increase the
risk of endometrial cancer (cancer of the uterus lining) in women after menopause.
The risk seems to increase as the dose and the length of use increase. When
estrogens are used in low doses for less than one year, there is less risk.
The risk is also reduced if a progestin (another female hormone) is added
to, or replaces part of, your estrogen dose. If the uterus has been removed
by surgery (total hysterectomy), there is no risk of endometrial cancer.
It is not yet known whether the use of estrogens increases the risk
of breast cancer in women. Although some large studies show an increased risk,
most studies and information gathered to date do not support this idea.
Along with its needed effects, a medicine may cause some unwanted effects.
Although not all of these side effects may occur, if they do occur they may
need medical attention.
Check with your doctor
if any of the following side effects occur:
Also, check with your doctor
as soon as possible if any of the following side effects occur:
Acne or oily skin (severe); breast pain
or tenderness; changes in vaginal bleeding (spotting,
breakthrough bleeding, prolonged or heavier bleeding, or complete stoppage
of bleeding); enlarged clitoris; enlargement or decrease in size of breasts; hoarseness
or deepening of voice; swelling of feet or lower
legs; unnatural hair growth; unusual hair loss; weight gain (rapid)
Less common or rare
Confusion; dizziness; flushing or redness of skin; headaches (frequent
or continuing); hives (especially at place of injection); shortness of breath (unexplained); skin rash, hives, or itching; unusual
bleeding; unusual tiredness or drowsiness
With long-term use or high doses
Black, tarry, or light-colored stools; dark-colored urine; general feeling of discomfort
or illness (continuing); hives (frequent or continuing); loss of appetite (continuing); lump in, or discharge from breast; nausea (severe); pain, swelling, or tenderness in stomach or upper
abdomen (continuing); purple- or red-colored spots
on body or inside the mouth or nose; sore throat
or fever (continuing); unpleasant breath odor (continuing); vomiting (severe)
Other side effects may occur
that usually do not need medical attention. These side effects may go away
during treatment as your body adjusts to the medicine. However, check with
your doctor if any of the following side effects continue or are bothersome:
Constipation; diarrhea (mild); dizziness (mild); headaches (mild); infection, redness, pain, or other irritation at place of injection; migraine headaches; problems
in wearing contact lenses; trouble in sleeping
Also, many women who are taking a progestin (another
type of female hormone) with this medicine will begin to have monthly vaginal
bleeding again, similar to menstrual periods. This effect will continue for
as long as this medicine is used. However, monthly bleeding will not occur
in women who have had the uterus removed by surgery (total hysterectomy).
Other side effects not listed above may also occur in
some patients. If you notice any other effects, check with your doctor.