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You are here : 3-RX.com > Drugs & Medications > Detailed Drug Information (USP DI) > Antihistamines, Decongestants, and Analgesics : Before Using

Antihistamines, Decongestants, and Analgesics (Systemic)

Antihistamines, Decongestants, and Analgesics | Before Using | Proper Use | Precautions | Side Effects

Before Using This Medicine

If you are taking this medicine without a prescription, carefully read and follow any precautions on the label. For antihistamine, decongestant, and analgesic combinations, the following should be considered:

Allergies - Tell your doctor if you have ever had any unusual or allergic reaction to any of the ingredients contained in this medicine. If this medicine contains aspirin or another salicylate , before taking it, check with your doctor if you have ever had any unusual or allergic reaction to any of the following medicines:

  • Diclofenac (e.g., Voltaren)
  • Diflunisal (e.g., Dolobid)
  • Etodolac (e.g., Lodine)
  • Fenoprofen (e.g., Nalfon)
  • Floctafenine
  • Flurbiprofen, by mouth (e.g., Ansaid)
  • Ibuprofen (e.g., Motrin)
  • Indomethacin (e.g., Indocin)
  • Ketoprofen (e.g., Orudis)
  • Meclofenamate (e.g., Meclomen)
  • Mefenamic acid (e.g., Ponstel)
  • Methyl salicylate (oil of wintergreen)
  • Nabumetone (e.g., Relafen)
  • Naproxen (e.g., Naprosyn)
  • Oxaprozin (e.g., Daypro)
  • Oxyphenbutazone (e.g., Tandearil)
  • Phenylbutazone (e.g., Butazolidin)
  • Piroxicam (e.g., Feldene)
  • Sulindac (e.g., Clinoril)
  • Suprofen (e.g., Suprol)
  • Tenoxicam (e.g., Mobiflex)
  • Tiaprofenic acid (e.g., Surgam)
  • Tolmetin (e.g., Tolectin)
  • Zomepirac (e.g., Zomax)

Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy - The occasional use of antihistamine, decongestant, and analgesic combinations is not likely to cause problems in the fetus or in the newborn baby. However, when these medicines are used at higher doses and/or for a long time, the chance that problems might occur may increase. For the individual ingredients of these combinations, the following apply:

  • Acetaminophen - Acetaminophen has not been shown to cause birth defects or other problems in humans. However, studies on birth defects have not been done in humans.
  • Alcohol - Some of these combination medicines contain large amounts of alcohol. Too much use of alcohol during pregnancy may cause birth defects.
  • Antihistamines - Antihistamines have not been shown to cause problems in humans.
  • Caffeine - Studies in humans have not shown that caffeine causes birth defects. However, studies in animals have shown that caffeine causes birth defects when given in very large doses (amounts equal to the amount of caffeine contained in 12 to 24 cups of coffee a day).
  • Phenylephrine - Studies on birth defects have not been done in either humans or animals with phenylephrine.
  • Pseudoephedrine - Studies on birth defects with pseudoephedrine have not been done in humans. In animal studies pseudoephedrine did not cause birth defects but did cause a decrease in average weight, length, and rate of bone formation in the animal fetus when administered in high doses.
  • Salicylates (e.g., aspirin) - Salicylates have not been shown to cause birth defects in humans. Studies on birth defects in humans have been done with aspirin. However, salicylates have been shown to cause birth defects in animals.
    Regular use of salicylates late in pregnancy may cause unwanted effects on the heart or blood flow in the fetus or newborn baby. Use of salicylates during the last 2 weeks of pregnancy may cause bleeding problems in the fetus before or during delivery, or in the newborn baby. Also, too much use of salicylates during the last 3 months of pregnancy may increase the length of pregnancy, prolong labor, cause other problems during delivery, or cause severe bleeding in the mother before, during, or after delivery. Do not take aspirin during the last 3 months of pregnancy unless it has been ordered by your doctor .

Breast-feeding - If you are breast-feeding the chance that problems might occur depends on the ingredients of the combination. For the individual ingredients of these combinations, the following apply:

  • Acetaminophen - Acetaminophen passes into the breast milk. However, it has not been shown to cause problems in nursing babies.
  • Alcohol - Alcohol passes into the breast milk. However, the amount of alcohol in recommended doses of this medicine does not usually cause problems in nursing babies.
  • Antihistamines - Use is not recommended since the chances are greater for this medicine to cause side effects, such as unusual excitement or irritability, in the nursing baby. Also, since antihistamines tend to decrease the secretions of the body, it is possible that the flow of breast milk may be reduced in some women.
  • Caffeine - Small amounts of caffeine pass into the breast milk and may build up in the nursing baby. However, the amount of caffeine in recommended doses of this medicine does not usually cause problems in nursing babies.
  • Decongestants (e.g., phenylephrine, pseudoephedrine) - Decongestants may pass into the breast milk and may cause unwanted effects in nursing babies of mothers taking this medicine.
  • Salicylates (e.g., aspirin, sodium salicylate) - Salicylates pass into the breast milk. Although salicylates have not been reported to cause problems in nursing babies, it is possible that problems may occur if large amounts are taken regularly.

Children - Very young children are usually more sensitive to the effects of this medicine. Increases in blood pressure, nightmares, unusual excitement, nervousness, restlessness, or irritability may be more likely to occur in children. Also, mental changes may be more likely to occur in young children taking these combination medicines.

Before giving any of these combination medicines to a child, check the package label very carefully. Some of these medicines are too strong for use in children . If you are not certain whether a specific product can be given to a child, or if you have any questions about the amount to give, check with your health care professional.

Do not give aspirin or other salicylates to a child with a fever or other symptoms of a virus infection, especially flu or chickenpox, without first discussing their use with your child's doctor . This is very important because salicylates may cause a serious illness called Reye's syndrome in children with fever caused by a virus infection, especially flu or chickenpox. Also, children may be more sensitive to the aspirin or other salicylates contained in some of these medicines, especially if they have a fever or have lost large amounts of body fluid because of vomiting, diarrhea, or sweating.

Adolescents - Do not give aspirin or other salicylates to a teenager with a fever or other symptoms of a virus infection, especially flu or chickenpox, without first discussing their use with your child's doctor . This is very important because salicylates may cause a serious illness called Reye's syndrome in teenagers with fever caused by a virus infection, especially flu or chickenpox.

Older adults - The elderly are usually more sensitive to the effects of this medicine. Confusion, difficult or painful urination, dizziness, drowsiness, feeling faint, or dryness of mouth, nose, or throat may be more likely to occur in elderly patients. Also, nightmares or unusual excitement, nervousness, restlessness, or irritability may be more likely to occur in the elderly.

Other medicines - Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking antihistamine, decongestant, and analgesic combinations it is especially important that your health care professional know if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine, for example, aspirin or other medicine for allergies. Some medicines may change the way this medicine affects your body. Also, the effect of other medicines may be increased or reduced by some of the ingredients in this medicine.

Other medical problems - The presence of other medical problems may affect the use of antihistamine, decongestant, and analgesic combinations. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse - Acetaminophen-containing medicines increase the chance of liver damage
  • Anemia - Taking a salicylate-containing medicine may make the anemia worse
  • Asthma, allergies, and nasal polyps, history of, or
  • Asthma attacks - Taking a salicylate-containing medicine may cause an allergic reaction in which breathing becomes difficult; also, although antihistamines open tightened bronchial passages, other effects of the antihistamines may cause secretions to become thick so that during an asthma attack it might be difficult to cough them up
  • Diabetes mellitus (sugar diabetes) - The decongestant in this medicine may put the patient with diabetes at a greater risk of having heart or blood vessel disease
  • Enlarged prostate or
  • Urinary tract blockage or difficult urination - Some of the effects of antihistamines may cause urinary problems to get worse
  • Glaucoma - A slight increase in inner eye pressure may occur
  • Gout - Aspirin- or sodium salicylate-containing medicine may make the gout worse and reduce the benefit of the medicines used for gout
  • Hemophilia or other bleeding problems - Aspirin- or sodium salicylate-containing medicine increases the chance of bleeding
  • Hepatitis or other liver disease - There is a greater chance of side effects because the medicine is not broken down and may build up in the body; also, if liver disease is severe there is a greater chance that aspirin-containing medicine may cause bleeding
  • Heart or blood vessel disease or
  • High blood pressure - The decongestant in this medicine may cause the blood pressure to increase and may also speed up the heart rate; also, caffeine-containing medicine, if taken in large amounts, may have a similar effect on the heart
  • Kidney disease (severe) - The kidneys may be affected, especially if too much of this medicine is taken for a long time
  • Overactive thyroid - If the overactive thyroid has caused a fast heart rate, the decongestant in this medicine may cause the heart rate to speed up further
  • Stomach ulcer or other stomach problems - Salicylate-containing medicine may make the ulcer worse or cause bleeding of the stomach

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Antihistamines, Decongestants, and Analgesics: Description and Brand Names

 

Antihistamines, Decongestants, and Analgesics: Proper Use



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