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You are here : 3-RX.com > Drugs & Medications > Detailed Drug Information (USP DI) > Antihistamines, Decongestants, and Analgesics : Side Effects

Antihistamines, Decongestants, and Analgesics (Systemic)

Antihistamines, Decongestants, and Analgesics | Before Using | Proper Use | Precautions | Side Effects

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although serious side effects occur rarely when this medicine is taken as recommended, they may be more likely to occur if:

  • too much medicine is taken
  • it is taken in large doses
  • it is taken for a long time

Get emergency help immediately if any of the following symptoms of overdose occur :

    For all combinations

      Clumsiness or unsteadiness; convulsions (seizures); drowsiness (severe); dryness of mouth, nose, or throat (severe); fast heartbeat; flushing or redness of face; hallucinations (seeing, hearing, or feeling things that are not there); headache (continuing and/or severe); increased sweating; nausea or vomiting (severe or continuing); shortness of breath or troubled breathing; stomach cramps or pain (severe or continuing); trouble in sleeping

    For acetaminophen-containing only

      Diarrhea; loss of appetite; swelling or tenderness in the upper abdomen or stomach area


      Signs of severe acetaminophen overdose may not appear until 2 to 4 days after the overdose is taken, but treatment to prevent liver damage or death must be started within 24 hours or less after the overdose is taken.

    For salicylate-containing only

      Any loss of hearing; bloody urine; changes in behavior (in children); confusion; diarrhea (severe or continuing); drowsiness or tiredness (severe, especially in children); fast or deep breathing (especially in children); fever; ringing or buzzing in ears (continuing); uncontrollable flapping movements of the hands (especially in elderly patients); unusual thirst; vision problems

Also, check with your doctor as soon as possible if any of the following side effects occur:

    More common

      Nausea or vomiting; stomach pain (mild)

    Less common or rare

      Bloody or black tarry stools; changes in urine or problems with urination; skin rash, hives, or itching; sore throat and fever; swelling of face, feet, or lower legs; tightness in chest; unusual bleeding or bruising; unusual tiredness or weakness; vomiting of blood or material that looks like coffee grounds; weight gain (unusual); yellow eyes or skin

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

    More common

      Drowsiness; heartburn or indigestion (for salicylate-containing medicines); thickening of mucus

    Less common - more common with high doses

      Blurred vision; confusion; difficult or painful urination; dizziness; dryness of mouth, nose, or throat; headache; loss of appetite; nightmares; pounding heartbeat; ringing or buzzing in ears; skin rash; stomach upset or stomach pain; unusual excitement, nervousness, restlessness, or irritability

Not all of the side effects listed above have been reported for each of these medicines, but they have been reported for at least one of them. There are some similarities among these combination medicines, so many of the above side effects may occur with any of these medicines.

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

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Antihistamines, Decongestants, and Analgesics: Precautions


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