Daunorubicin, Liposomal (Systemic)
Brand Names : DaunoXome
Before Receiving This MedicineIn deciding to use a medicine, the risks of taking the medicine must be
weighed against the good it will do. This is a decision you and your doctor
will make. For liposomal daunorubicin, the following should be considered:
Allergies - Tell your doctor if you have ever had any unusual or
allergic reaction to liposomal daunorubicin. Also, tell your health care professional
if you are allergic to any other substances, such as preservatives.
Pregnancy - Liposomal daunorubicin has not been studied in pregnant
women. However, studies in rats have shown that liposomal daunorubicin at
low doses causes birth defects or death of the fetus. Before receiving this medicine, make sure your doctor knows if you are
pregnant or may become pregnant. It is best to use some kind of birth control
while you are receiving liposomal daunorubicin. Tell your doctor right away
if you think you have become pregnant while receiving liposomal daunorubicin.
Breast-feeding - Because liposomal daunorubicin may cause serious
side effects in the infant, breast-feeding is generally not recommended while
you are receiving it.
Children - There is no specific information comparing the use
of liposomal daunorubicin in children with use in any other age group. Safety
and efficacy of liposomal daunorubicin in children have not been established.
Older adults - There is no specific information comparing the use
of liposomal daunorubicin in the elderly with use in any other age group.
Safety and efficacy of liposomal daunorubicin in the elderly have not been
established.
Other medicines - Although certain medicines should not be used
together at all, in other cases two different medicines may be used together
even if an interaction might occur. In these cases, your doctor may want to
change the dose, or other precautions may be necessary. When you are taking
liposomal daunorubicin, it is especially important that your health care professional
know if you are taking any of the following:
-
Amphotericin B by injection (e.g., Fungizone) or
-
Antithyroid agents (medicine for overactive thyroid) or
-
Azathioprine (e.g., Imuran) or
-
Chloramphenicol (e.g., Chloromycetin) or
-
Colchicine or
-
Cyclophosphamide (e.g., Cytoxan) or
-
Flucytosine (e.g., Ancobon) or
-
Ganciclovir (e.g., Cytovene) or
-
Interferon (e.g., Intron A, Roferon-A) or
-
Mercaptopurine (e.g., Purinethol) or
-
Methotrexate (e.g., Mexate) or
-
Plicamycin (e.g., Mithracin) or
-
Zidovudine (e.g., AZT, Retrovir) or
-
If you have ever been treated with radiation or cancer medicines - Liposomal
daunorubicin may increase the effects of these medicines or radiation therapy
on the blood
-
Probenecid (e.g., Benemid) or
-
Sulfinpyrazone (e.g., Anturane) - Liposomal daunorubicin may
raise the concentration of uric acid in the blood. Since these medicines are
used to lower uric acid levels, they may not be as effective in patients receiving
liposomal daunorubicin
Other medical problems - The presence of other medical
problems may affect the use of liposomal daunorubicin. Make sure you tell
your doctor if you have any other medical problems, especially:
-
Chickenpox (including recent exposure) or
-
Herpes zoster (shingles) - Risk of severe disease affecting other
parts of the body
-
Gout (history of) or
-
Kidney stones - Liposomal daunorubicin may increase uric acid
in the body, which can cause gout or kidney stones
-
Heart disease - Risk of heart problems caused by liposomal daunorubicin
may be increased
-
Infection - Liposomal daunorubicin can decrease your body's ability
to fight infection
-
Kidney disease or
-
Liver disease - Effects of liposomal daunorubicin may be increased
because of slower removal from the body
|