Dinoprostone (Cervical/Vaginal)

Brand Names : Cervidil, Prepidil, Prostin E, prostaglandin E 2, PGE 2

Before Receiving This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For dinoprostone, the following should be considered:

Allergies - Tell your doctor if you have ever had any unusual or allergic reaction to dinoprostone, misoprostol, oxytocin or other medicines that stimulate the uterus to contract.

Other medicines - Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving dinoprostone, it is especially important that your doctor knows if you are using any other vaginal prescription or nonprescription (over-the-counter [OTC]) medicine.

Other medical problems - The presence of other medical problems may affect the use of dinoprostone. Make sure you tell your doctor if you have any other medical problems, especially:

• Anemia (or history of) - Dinoprostone, when used in doses that stimulate the uterus to contract, may result in loss of blood in some patients that may require a blood transfusion

• Asthma (or history of, including childhood asthma) or
• Lung disease - Dinoprostone may cause narrowing of the blood vessels in the lungs or narrowing of the lung passages, especially when it is used in doses that stimulate the uterus to contract

• Epilepsy (or history of) - Rarely, seizures have occurred with dinoprostone when it is used in doses that stimulate the uterus to contract

• Glaucoma - Rarely, the pressure within the eye has increased and constriction of the pupils has occurred during the use of medicines like dinoprostone; this may also be a problem with dinoprostone when it is used in doses that stimulate the uterus to contract

• Heart or blood vessel disease (or history of) or
• High blood pressure (or history of) or
• Low blood pressure (history of) - Dinoprostone may cause changes in heart function or blood pressure changes; two patients with a history of heart disease had heart attacks when dinoprostone was used in doses that stimulated the uterus to contract

• Kidney disease (or history of) or
• Liver disease (or history of) - The body may not remove dinoprostone from the blood stream at the usual rate, which may make the dinoprostone work longer or cause an increased chance of side effects, especially when dinoprostone is used in doses that stimulate the uterus to contract

• Problems during delivery, history of or
• Surgery of uterus (history of) or
• Unusual vaginal bleeding - There is an increased risk of problems occurring with dinoprostone when it is used in doses that stimulate the uterus to contract