Ifosfamide (Systemic)
Brand Names : IFEX
Before Using This MedicineIn deciding to use a medicine,
the risks of taking the medicine must be weighed against the good it will
do. This is a decision you and your doctor will make. For ifosfamide, the
following should be considered:
Allergies - Tell your doctor if you have ever had any unusual or
allergic reaction to ifosfamide.
Pregnancy - Tell your doctor if you are pregnant or if you intend
to have children. There is a chance that this medicine may cause birth defects
if either the male or female is taking it at the time of conception or if
it is taken during pregnancy. Ifosfamide causes birth defects in animals.
In addition, many cancer medicines may cause sterility that could be permanent.
Although sterility has not been reported with this medicine, the possibility
should be kept in mind. Be sure that you have discussed this with your doctor before taking this
medicine. It is best to use some kind of birth control while you are receiving
ifosfamide. Tell your doctor right away if you think you have become pregnant
while receiving ifosfamide.
Breast-feeding - Tell your doctor if you are breast-feeding or if
you intend to breast-feed during treatment with this medicine. Because ifosfamide
may cause serious side effects in the nursing infant, breast-feeding is generally
not recommended while you are receiving it.
Children - Although there is no specific information comparing
use of ifosfamide in children with use in other age groups, this medicine
is not expected to cause different side effects or problems in children than
it does in adults.
Older adults - Many medicines have not been studied specifically
in older people. Therefore, it may not be known whether they work exactly
the same way they do in younger adults or if they cause different side effects
or problems in older people. There is no specific information comparing use
of ifosfamide in the elderly with use in other age groups.
Other medicines - Although certain medicines should not be used
together at all, in other cases two different medicines may be used together
even if an interaction might occur. In these cases, your doctor may want to
change the dose, or other precautions may be necessary. When you are taking
ifosfamide, it is especially important that your health care professional
know if you are taking any of the following:
-
Amphotericin B by injection (e.g., Fungizone) or
-
Antithyroid agents (medicine for overactive thyroid) or
-
Azathioprine (e.g., Imuran) or
-
Chloramphenicol (e.g., Chloromycetin) or
-
Colchicine or
-
Flucytosine (e.g., Ancobon) or
-
Ganciclovir (e.g., Cytovene) or
-
Interferon (e.g., Intron A, Roferon-A) or
-
Plicamycin (e.g., Mithracin) or
-
Zidovudine (e.g., AZT, Retrovir) or
-
If you have ever been treated with x-rays or cancer medicines - Ifosfamide
may increase the effects of these medicines or radiation therapy on the blood
Other medical problems - The presence of other medical
problems may affect the use of ifosfamide. Make sure you tell your doctor
if you have any other medical problems, especially:
-
Chickenpox (including recent exposure) or
-
Herpes zoster (shingles) - Risk of severe disease affecting other
parts of the body
-
Infection - Ifosfamide can decrease your body's ability to fight
infection
-
Kidney disease - Effects may be increased because of slower removal
of ifosfamide from the body
-
Liver disease - Effects may be increased or decreased because
the liver both makes ifosfamide work and removes it from the body
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