Lamotrigine (Systemic)

Brand Names : Lamictal, LTG

Proper Use of This Medicine

Take lamotrigine only as directed by your doctor to help your condition as much as possible and to decrease the chance of unwanted effects. Do not take more or less of this medicine, and do not take it more or less often than your doctor ordered.

Lamotrigine may be taken with or without food or on a full or empty stomach. However, if your doctor tells you to take the medicine a certain way, take it exactly as directed.

If you are taking the chewable/dispersible tablets : These tablets may be swallowed whole, chewed and swallowed, or dispersed in a small amount of liquid and swallowed. If the tablets are chewed, they should be followed with a small amount of water or diluted fruit juice to aid in swallowing. If tablets are to be dispersed: Place tablets in enough water or diluted fruit juice to cover the tablets (about a teaspoonful), wait until the tablets are completely dispersed (about 1 minute), then swirl the solution and swallow it immediately.

Dosing - The dose of lamotrigine will be different for different patients, and depends on what other medicines you are taking. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of lamotrigine. If your dose is different, do not change it unless your doctor tells you to do so.

The number of tablets that you take depends on the strength of the medicine.

• For oral dosage forms (tablets):
  • For treatment of epilepsy:
    • Adults not taking valproic acid (e.g., Depakote) but taking carbamazepine (e.g., Tegretol), phenobarbital (e.g., Luminal), phenytoin (e.g., Dilantin), and/or primidone (e.g., Mysoline) - At first, 50 milligrams (mg) of lamotrigine once a day for two weeks, then a total of 100 mg divided into two smaller doses each day for two weeks. After this, your doctor may increase the dose gradually if needed. However, the dose is usually not more than 500 mg a day.
    • Adults taking valproic acid (e.g., Depakote) and also taking carbamazepine (e.g., Tegretol), phenobarbital (e.g., Luminal), phenytoin (e.g., Dilantin), and/or primidone (e.g., Mysoline) - At first, 25 mg of lamotrigine once every other day for two weeks, then 25 mg once every day for two weeks. After this, your doctor may increase the dose gradually if needed. However, the dose is usually not more than 400 mg a day.
    • Children 2 to 12 years of age:
      • Children not taking valproic acid (e.g., Depakote) but taking carbamazepine (e.g., Tegretol), phenobarbital (e.g., Luminal), phenytoin (e.g., Dilantin), and/or primidone (e.g., Mysoline): At first, 0.6 milligrams (mg) per kilogram (kg) (0.27 mg per pound) of body weight of lamotrigine once a day for two weeks, then 1.2 mg/kg (0.54 mg per pound) of body weight divided into two smaller doses each day for two weeks. After this, your doctor may increase the dose gradually if needed. However, the dose is usually not more than 400 mg a day.
      • Children taking valproic acid (e.g., Depakote) and also taking carbamazepine (e.g., Tegretol), phenobarbital (e.g., Luminal), phenytoin (e.g., Dilantin), and/or primidone (e.g., Mysoline): At first, 0.15 mg per kg (0.07 mg per pound) of body weight of lamotrigine given in one dose or two smaller doses each day for two weeks, then 0.3 mg/kg (0.136 mg per pound) of body weight given in one dose or two smaller doses each day for two weeks. After this, your doctor may increase the dose gradually if needed. However, the dose is usually not more than 200 mg a day.
    • Children older than 12 years of age usually receive the adult dose.

Missed dose - If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage - To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.