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You are here : 3-RX.com > Drugs & Medications > Detailed Drug Information (USP DI) > Mafenide : Before Using

Mafenide (Topical)

Brand Names : Sulfamylon

Mafenide | Before Using | Proper Use | Precautions | Side Effects

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For mafenide, the following should be considered:

Allergies - Tell your doctor if you have ever had any unusual or allergic reaction to mafenide, acetazolamide (e.g., Diamox), oral antidiabetics (diabetes medicine you take by mouth), dichlorphenamide (e.g., Daranide), furosemide (e.g., Lasix), methazolamide (e.g., Neptazane), other sulfa medicines, or thiazide diuretics (water pills). Also tell your health care professional if you are allergic to any other substances, such as preservatives or dyes.

Pregnancy - Studies on effects in pregnancy have not been done in either humans or animals. However, use is not recommended in women during their child-bearing years unless the burn area covers more than 20% of the total body surface. In addition, sulfa medicines may increase the chance of liver problems in newborn infants and should not be used near the due date of the pregnancy.

Breast-feeding - Mafenide, when used on skin and/or burns, is absorbed into the mother's body. It is not known whether this medicine passes into breast milk. Sulfa medicines given by mouth do pass into the breast milk, and may cause liver problems, anemia (iron-poor blood), and other unwanted effects in nursing babies, especially those with glucose-6-phosphate dehydrogenase deficiency (lack of G6PD enzyme). Be sure you have discussed the risks and benefits of mafenide with your doctor.

Children - Use of mafenide is not recommended in premature or newborn infants up to 2 months of age. Sulfa medicines may cause liver problems in these infants.

Older adults - Many medicines have not been tested in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of mafenide in the elderly with use in other age groups.

Other medicines - Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are using any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other medical problems - The presence of other medical problems may affect the use of mafenide. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood problems - Use of mafenide may make the condition worse
  • Glucose-6-phosphate dehydrogenase deficiency (lack of G6PD enzyme) - Use of mafenide in persons with this condition may result in hemolytic anemia
  • Kidney problems or
  • Lung problems or
  • Metabolic acidosis - Use of mafenide in persons with any of these conditions may increase the risk of a side effect called metabolic acidosis

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Mafenide: Description and Brand Names


Mafenide: Proper Use

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