Brand Names : chlormethine, ntirogen mustard
Proper Use of This Medicine
Mechlorethamine may be used
either as a solution or as an ointment. If you are using the solution, it
must be mixed just before you use it since it breaks down quickly. Mix the solution carefully according to your doctor's or pharmacist's
When preparing the solution, remember:
Do not use the mechlorethamine if the solution is discolored or if
droplets of water appear in the vial.
Avoid inhaling the powder or any vapors. If some of the powder or
solution accidentally gets on your skin, immediately
wash that area of skin. Use a large amount of water and continue to
wash for at least 15 minutes. If eye contact occurs, use an eyewash recommended
by your doctor. Keep this eyewash on hand. Follow carefully
any other instructions your doctor may have given you
All equipment used must be specially cleaned, even if it is to be
thrown away. Follow carefully your doctor's instructions
for doing this, using the special solution recommended.
Take a shower and rinse carefully just before you apply mechlorethamine
solution or ointment, unless otherwise directed by your doctor. Make sure
your skin is completely dry before applying the ointment. Do not shower again
until the next treatment.
Apply the solution or ointment all over the body, until the entire amount
for a dose is used up. Wear rubber or plastic gloves if you are using your
hands. To apply the solution, a 2-inch-wide soft brush or gauze may be used
instead. Let the solution dry.
Mechlorethamine should be applied more lightly to the groin, armpits, inside
the bends of the elbows, and behind the knees. These areas are more likely
to get irritated.
Avoid contact with the eyes, nose, or mouth, unless otherwise directed
by your doctor.
Mechlorethamine is usually applied once a day. However, follow your doctor's
instructions. Continue to use the medicine as long as you are told to. This
may be months or years. However, do not use this medicine more often or for
a longer time than ordered. To do so may increase the chance of unwanted effects.
Dosing - The dose of mechlorethamine will be different
for different patients. Follow your doctor's orders or
the directions on the label
. The following information includes only
the average doses of mechlorethamine. If your dose is
different, do not change it
unless your doctor tells you to do so.
dosage forms (ointment or
For mycosis fungoides:
Adults - Apply to the entire skin surface once a day. Several
months after this medicine has helped your problem, your doctor may decrease
the treatments to several times a week.
Children - Dose must be determined by your doctor.
Missed dose - If you miss a dose of this medicine, go back to
your regular dosing schedule and check with your doctor. Do not change the
amount you are using unless directed to do so by your doctor.
Storage - To store this medicine:
Keep out of the reach of children.
Store away from heat and direct light. This applies to either the
ointment or the vials of mechlorethamine used to make the solution. The solution
should not be stored but instead should be freshly made just before it is
Do not store in the bathroom, near the kitchen sink, or in other
damp places. Heat or moisture may cause the medicine to break down.
Do not keep outdated medicine or medicine no longer needed. Be sure
that any discarded medicine is out of the reach of children.