Methotrexate For Noncancerous Conditions (Systemic)
Brand Names : Folex, Folex PFS, Methotrexate LPF, Rheumatrex, amethopterin
Before Using This Medicine
In deciding to use a medicine,
the risks of taking the medicine must be weighed against the good it will
do. This is a decision you and your doctor will make. For methotrexate, the
following should be considered:
Allergies - Tell your doctor if you have ever had any unusual or
allergic reaction to methotrexate.
Pregnancy - There is a good chance that this medicine may cause
birth defects if either the male or female is taking it at the time of conception
or if it is taken during pregnancy. Methotrexate may cause harm or even death
of the fetus. In addition, this medicine may rarely cause temporary sterility.
Methotrexate is not recommended during pregnancy. Be sure that you have
discussed this with your doctor before taking this medicine. It is best to
use some kind of birth control while you are taking methotrexate. Tell your
doctor right away if you think you have become pregnant while taking methotrexate.
Breast-feeding - Tell your doctor if you are breast-feeding or if
you intend to breast-feed during treatment with this medicine. Because methotrexate
may cause serious side effects, breast-feeding is generally not recommended
while you are taking it.
Children - Newborns and other infants may be more sensitive
to the effects of methotrexate. However, in other children it is not expected
to cause different side effects or problems than it does in adults.
Older adults - Side effects may be more likely to occur in the elderly,
who are usually more sensitive to the effects of methotrexate.
Other medicines - Although certain medicines should not be used
together at all, in other cases two different medicines may be used together
even if an interaction might occur. In these cases, your doctor may want to
change the dose, or other precautions may be necessary. When you are taking
methotrexate, it is especially important that your health care professional
know if you are taking any other prescription or nonprescription (over-the-counter
[OTC]) medicine. They should also be told if you have ever been treated with
x-rays or cancer medicines or if you drink alcohol.
Other medical problems - The presence of other medical
problems may affect the use of methotrexate. Make sure you tell your doctor
if you have any other medical problems, especially:
Alcohol abuse (or history of) - Increased risk of unwanted effects
on the liver
Chickenpox (including recent exposure) or
Herpes zoster (shingles) - Risk of severe disease affecting other
parts of the body
Disease of the immune system
Folate deficiency - May increase the chance of side effects
Infection - Methotrexate can reduce immunity to infection
Intestine blockage or
Kidney disease or
Liver disease - Effects may be increased because of slower removal
of methotrexate from the body
Mouth sores or inflammation or
Stomach ulcer - May be worsened