Niacin and Lovastatin (Systemic)
Brand Names : Advicor
Before Using This Medicine
combination medicine should not be used until after your body has adjusted
to each of the individual medicines. Be sure to check with your doctor about
In deciding to use a medicine, the risks of taking the medicine must be
weighed against the good it will do. This is a decision you and your doctor
will make. For niacin extended-release and lovastatin combination, the following
should be considered:
Allergies - Tell your doctor if you have ever had any unusual
or allergic reaction to niacin and lovastatin. Also tell your doctor and pharmacist
if you are allergic to any other substances, such as foods, preservatives,
Diet - Before prescribing medicine for your condition,
your doctor will probably try to control your condition by prescribing a personal
diet for you. Such a diet may be low in fats, particularly saturated fat,
sugars, and/or cholesterol. Many people are able to control their condition
by carefully following their doctor's orders for proper diet and exercise.
Medicine is prescribed only when additional help is needed
and is effective only when a schedule of diet and exercise is properly
Make certain your doctor knows if you are on any special diet, such as
a low-sodium or low-sugar diet.
Pregnancy - Niacin extended-release and lovastatin combination
should not be used during pregnancy or by women who plan to become pregnant
in the near future. This medicine blocks the formation of cholesterol, which
is necessary for the fetus to develop properly. Niacin extended-release and
lovastatin combination may cause birth defects or other problems in the baby
if taken during pregnancy. If you are a woman of child-bearing age and your
doctor wants you to take this medicine, it is very important that an effective
form of birth control be used during treatment with this medicine. Check with your doctor immediately if you think you have become pregnant while
taking this medicine.
Be sure you have discussed this with your doctor.
Breast-feeding - Niacin extended-release and lovastatin combination
is not recommended for use during breast-feeding because it may cause unwanted
effects in nursing babies.
Children - Studies on this medicine have been done only in
adult patients, and there is no specific information comparing use of niacin
extended-release and lovastatin combination in children with use in other
Older adults - This medicine has been tested in a limited number
of patients 65 years of age or older and has not been shown to cause different
side effects or problems in older people than it does in younger adults.
Other medicines - Although certain medicines should not be used
together at all, in other cases two different medicines may be used together
even if an interaction might occur. In these cases, your doctor may want to
change the dose, or other precautions may be necessary. When you are taking
niacin extended-release and lovastatin combination, it is especially important
that your doctor and pharmacist know if you are taking any of the following:
Alcohol, excessive use - Excessive amounts of alcohol while taking
niacin extended-release and lovastatin combination can worsen the adverse
effects of this medicine on the liver
Anticoagulants (blood thinners such as warfarin [Coumadin]) - Use
with niacin extended-release and lovastatin combination may increase the risk
Antihypertensives (medicine for high blood pressure) - Effects
on blood pressure may be increased.
Clarithromycin (e.g., Biaxin) or
Clofibrate (e.g., Atromid-S) or
Cyclosporine (e.g., Neoral, Sandimmune) or
Erythromycin (e.g., E-Mycin) or
Fenofibrate (e.g., Tricor) or
Gemfibrozil (e.g., Lopid) or
Itraconazole (e.g., Sporanox) or
Ketoconazole (e.g., Nizoral) or
Nefazodone (e.g., Serzone) or
Protease Inhibitors (medicine used to treat HIV and AIDS such as
indinavir [Crixivan], nelfinavir [Viracept], ritonavir [Norvir], and saquinavir
[Invirase]) - Use of these medicines with niacin extended-release and
lovastatin combination may increase the risk of developing muscle problems.
Vitamins or supplements containing niacin or related compounds such
as nicotinamide - Use of these medicines may increase the risk of developing
adverse effects from niacin extended-release and lovastatin combination.
Other medical problems - The presence of other medical
problems may affect the use of niacin extended-release and lovastatin combination.
Make sure you tell your doctor if you have any other medical problems, especially:
Bleeding problems or
Diabetes mellitus (sugar diabetes) or
Endocrine problems or
Heart Disease or
Liver disease or
Low blood pressure or
Stomach Ulcer - Niacin extended-release and lovastatin combination
may make these conditions worse.
Kidney Disease - Effects of niacin extended-release and lovastatin
combination may be increased because of slower removal of medicine from the