Nitrates Sublingual, Chewable, or Buccal (Systemic)
Category- Antianginal
- Vasodilator, congestive heart failure
DescriptionNitrates (NYE-trates) are used to treat the symptoms of angina (chest
pain). Depending on the type of dosage form and how it is taken, nitrates
are used to treat angina in three ways:
-
to relieve an attack that is occurring by using the medicine when
the attack begins;
-
to prevent attacks from occurring by using the medicine just before
an attack is expected to occur; or
-
to reduce the number of attacks that occur by using the medicine
regularly on a long-term basis.
Nitrates are available in different forms. Sublingual nitrates are generally
placed under the tongue where they dissolve and are absorbed through the lining
of the mouth. Some can also be used buccally, being placed under the lip or
in the cheek. The chewable dosage forms, after being chewed and held in the
mouth before swallowing, are absorbed in the same way. It is important to remember that each dosage form is different and that the
specific directions for each type must be followed if the medicine is to work
properly
.
Nitrates that are used to relieve the pain
of an angina attack include:
-
sublingual nitroglycerin;
-
buccal nitroglycerin;
-
sublingual isosorbide dinitrate; and
-
chewable isosorbide dinitrate.
Those that can be used to prevent expected attacks
of angina include:
-
sublingual nitroglycerin;
-
buccal nitroglycerin;
-
sublingual isosorbide dinitrate; and
-
chewable isosorbide dinitrate.
Products that are used regularly on a long-term basis to reduce the number of attacks
that occur include:
-
buccal nitroglycerin;
-
chewable isosorbide dinitrate; and
-
sublingual isosorbide dinitrate.
Nitrates work by relaxing blood vessels and increasing the supply of blood
and oxygen to the heart while reducing its work load.
Nitrates may also be used for other conditions as determined by your doctor.
The nitrates discussed here are available only with your doctor's prescription,
in the following dosage forms:
Buccal
-
Nitroglycerin
-
Extended-release tablets (U.S. and Canada)
Chewable
-
Isosorbide dinitrate
Sublingual
-
Isosorbide dinitrate
-
Tablets (U.S. and Canada)
-
Nitroglycerin
-
Tablets (U.S. and Canada)
Brand NamesSome commonly used brand names are:
In the U.S. -
- Isordil 1
- Nitrogard 2
- Nitrostat 2
- Sorbitrate 1
In Canada -
- Apo-ISDN 1
- Coronex 1
- Isordil 1
- Nitrostat 2
Another commonly used name is:
Note:
|
For quick reference, the following nitrates are numbered
to match the corresponding brand names.
|
This information applies to the following medicines: |
1. |
Isosorbide Dinitrate (eye-soe-SOR-bide dye-NYE-trate)‡§ |
2. |
Nitroglycerin (nye-troe-GLI-ser-in)‡§ |
Note:
|
This information does not
apply to amylnitrite. |
‡ Generic name product may be available
in the U.S. |
§ Generic name product may be available
in Canada |
|