Pentoxifylline (Systemic)

Brand Names : Trental, oxypentifylline

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For pentoxifylline, the following should be considered:

Allergies - Tell your doctor if you have ever had any unusual or allergic reaction to pentoxifylline or to other xanthines such as aminophylline, caffeine, dyphylline, ethylenediamine (contained in aminophylline), oxtriphylline, theobromine, or theophylline. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy - Pentoxifylline has not been studied in pregnant women. Studies in animals have not shown that it causes birth defects. However, at very high doses it has caused other harmful effects. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding - Pentoxifylline passes into breast milk. The medicine has not been reported to cause problems in nursing babies. However, pentoxifylline has caused noncancerous tumors in animals when given for a long time in doses much larger than those used in humans. Therefore, your doctor may not want you to breast-feed while taking it. Be sure that you discuss the risks and benefits of this medicine with your doctor.

Children - Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of pentoxifylline in children with use in other age groups.

Older adults - Side effects may be more likely to occur in the elderly, who are usually more sensitive than younger adults to the effects of pentoxifylline.

Other medicines - Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking pentoxifylline, it is important that your health care professional know if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine, or if you smoke tobacco.

Other medical problems - The presence of other medical problems may affect the use of pentoxifylline. Make sure you tell your doctor if you have any other medical problems, especially:

• Any condition in which there is a risk of bleeding (e.g., recent stroke) - Pentoxifylline may make the condition worse

• Kidney disease or
• Liver disease - The chance of side effects may be increased