Probenecid (Systemic)
Brand Names : Benemid, Probalan, Benuryl
Before Using This MedicineIn deciding to use a medicine,
the risks of taking the medicine must be weighed against the good it will
do. This is a decision you and your doctor will make. For probenecid, the
following should be considered:
Allergies - Tell your doctor if you have ever had any unusual or
allergic reaction to probenecid. Also tell your health care professional if
you are allergic to any other substances, such as foods, preservatives, or
dyes.
Pregnancy - Probenecid has not been shown to cause birth defects
or other problems in humans.
Breast-feeding - Probenecid has not been reported to cause problems
in nursing babies.
Children - Probenecid has been tested in children 2 to 14 years
of age for use together with antibiotics. It has not been shown to cause different
side effects or problems than it does in adults. Studies on the effects of
probenecid in patients with gout have been done only in adults. Gout is very
rare in children.
Older adults - Many medicines have not been studied specifically
in older people. Therefore, it may not be known whether they work exactly
the same way they do in younger adults. There is no specific information comparing
use of probenecid in the elderly with use in other age groups.
Other medicines - Although certain medicines should not be used
together at all, in other cases two different medicines may be used together
even if an interaction might occur. In these cases, your doctor may want to
change the dose, or other precautions may be necessary. When you are taking
probenecid, it is especially important that your health care professional
know if you are taking any of the following:
-
Antineoplastics (cancer medicine) - The chance of serious side
effects may be increased
-
Aspirin or other salicylates - These medicines may keep probenecid
from working properly for treating gout, depending on the amount of aspirin
or other salicylate that you take and how often you take it
-
Heparin - Probenecid may increase the effects of heparin, which
increases the chance of side effects
-
Indomethacin (e.g., Indocin) or
-
Ketoprofen (e.g., Orudis) or
-
Methotrexate (e.g., Mexate) - Probenecid may increase the blood
levels of these medicines, which increases the chance of side effects
-
Medicine for infection, including tuberculosis or virus infection - Probenecid
may increase the blood levels of many of these medicines. In some cases, this
is a desired effect and probenecid may be used to help the other medicine
work better. However, the chance of side effects is sometimes also increased
-
Nitrofurantoin (e.g., Furadantin) - Probenecid may keep nitrofurantoin
from working properly
-
Zidovudine (e.g., AZT, Retrovir) - Probenecid increases the blood
level of zidovudine and may allow lower doses of zidovudine to be used. However,
the chance of side effects is also increased
Other medical problems - The presence of other medical
problems may affect the use of probenecid. Make sure you tell your doctor
if you have any other medical problems, especially:
-
Blood disease or
-
Cancer being treated by antineoplastics (cancer medicine) or radiation
(x-rays) or
-
Kidney disease or stones (or history of) or
-
Stomach ulcer (history of) - The chance of side effects may be
increased
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