Precautions While Using This Medicine
Check the labels of all nonprescription (over-the-counter [OTC])
and prescription medicines you now take. If any contain aspirin or other salicylates
(including bismuth subsalicylate [e.g., Pepto-Bismol] or any shampoo or skin
medicine that contains salicylic acid or any other salicylate), check with
your health care professional
. Taking or using them together with this
medicine may cause an overdose.
If you will be taking salicylates for a long time (more than 5 days in
a row for children or 10 days in a row for adults) or in large amounts, your doctor should check your progress at regular visits
Check with your medical doctor or dentist:
If you are taking this medicine to relieve pain and the pain lasts
for more than 10 days (5 days for children) or if the pain gets worse, if
new symptoms occur, or if redness or swelling is present. These could be signs
of a serious condition that needs medical or dental treatment.
If you are taking this medicine to bring down a fever, and the fever
lasts for more than 3 days or returns, if the fever gets worse, if new symptoms
occur, or if redness or swelling is present. These could be signs of a serious
condition that needs treatment.
If you are taking this medicine for a sore throat, and the sore throat
is very painful, lasts for more than 2 days, or occurs together with or is
followed by fever, headache, skin rash, nausea, or vomiting.
If you are taking this medicine regularly, as for arthritis (rheumatism),
and you notice a ringing or buzzing in your ears or severe or continuing headaches.
These are often the first signs that too much salicylate is being taken. Your
doctor may want to change the amount of medicine you are taking every day.
For patients taking aspirin to lessen the chance of
heart attack, stroke, or other problems caused by blood clots
Take only the amount of aspirin ordered by your
. If you need a medicine to relieve pain, a fever, or arthritis,
your doctor may not want you to take extra aspirin. It is a good idea to discuss
this with your doctor, so that you will know ahead of time what medicine to
Do not stop taking this medicine for any reason
without first checking with the doctor who directed you to take it
Taking certain other medicines together with a salicylate may increase
the chance of unwanted effects. The risk will depend on how much of each medicine
you take every day, and on how long you take the medicines together. If your
doctor directs you to take these medicines together on a regular basis, follow
his or her directions carefully. However, do not take
any of the following medicines together with a salicylate for more than a
few days, unless your doctor has directed you to do so and is following your
Acetaminophen (e.g., Tylenol)
Diclofenac (e.g., Voltaren)
Diflunisal (e.g., Dolobid)
Etodolac (e.g., Lodine)
Fenoprofen (e.g., Nalfon)
Floctafenine (e.g., Idarac)
Flurbiprofen, oral (e.g., Ansaid)
Ibuprofen (e.g., Motrin)
Indomethacin (e.g., Indocin)
Ketoprofen (e.g., Orudis)
Ketorolac (e.g., Toradol)
Meclofenamate (e.g., Meclomen)
Mefenamic acid (e.g., Ponstel)
Nabumetone (e.g., Relafen)
Naproxen (e.g., Naprosyn)
Oxaprozin (e.g., Daypro)
Phenylbutazone (e.g., Butazolidin)
Piroxicam (e.g., Feldene)
Sulindac (e.g., Clinoril)
Tenoxicam (e.g., Mobiflex)
Tiaprofenic acid (e.g., Surgam)
Tolmetin (e.g., Tolectin)
For diabetic patients
False urine sugar test results may occur if you are regularly taking
large amounts of salicylates, such as:
: 8 or more 325-mg (5-grain), or
4 or more 500-mg or 650-mg (10-grain), or 3 or more 800-mg (or higher strength),
doses a day.
Buffered aspirin or
: 8 or more 325-mg (5-grain),
or 4 or more 500-mg or 650-mg (10-grain), doses a day.
: 4 or more teaspoonfuls
(each teaspoonful containing 870 mg) a day.
Choline and magnesium salicylates
: 5 or
more 500-mg tablets or teaspoonfuls, 4 or more 750-mg tablets, or 2 or more
1000-mg tablets, a day.
: 7 or more regular-strength,
or 4 or more extra-strength, tablets a day.
: 4 or more 500-mg doses, or
3 or more 750-mg doses, a day.
Smaller doses or occasional use of salicylates usually will not affect
urine sugar tests. However, check with your health care professional (especially
if your diabetes is not well-controlled) if:
you are not sure how much salicylate you are taking every day.
you notice any change in your urine sugar test results.
you have any other questions about this possible problem.
Do not take aspirin for 5 days before any surgery, including dental surgery,
unless otherwise directed by your medical doctor or dentist. Taking aspirin
during this time may cause bleeding problems.
For patients taking buffered aspirin, choline and
magnesium salicylates (e.g., Trilisate), or magnesium salicylate (e.g., Doan's)
Buffered aspirin, choline and magnesium salicylates, or magnesium
salicylate can keep many other medicines, especially some medicines used to
treat infections, from working properly. This problem can be prevented by
not taking the 2 medicines too close together. Ask your health care professional
how long you should wait between taking a medicine for infection and taking
buffered aspirin, choline and magnesium salicylates, or magnesium salicylate.
If you are taking a laxative containing cellulose, take the salicylate
at least 2 hours before or after you take the laxative. Taking these medicines
too close together may lessen the effects of the salicylate.
For patients taking this medicine by mouth:
Stomach problems may be more likely to occur if you drink alcoholic
beverages while being treated with this medicine, especially if you are taking
it in high doses or for a long time. Check with your doctor if you have any
questions about this.
For patients using aspirin suppositories
Aspirin suppositories may cause irritation of the rectum. Check with
your doctor if this occurs.
Salicylates may interfere with the results of some medical tests. Before
you have any medical tests, tell the doctor in charge if you have taken any
of these medicines within the past week. If possible, it is best to check
with the doctor first, to find out whether the medicine may be taken during
the week before the test.
For patients taking one of the products that contain caffeine
Caffeine may interfere with the result of a test that uses adenosine
(e.g., Adenocard) or dipyridamole (e.g., Persantine) to help find out how
well your blood is flowing through certain blood vessels. Therefore, you should
not have any caffeine for at least 8 to 12 hours before the test.
If you think that you or anyone else may have taken
an overdose, get emergency help at once
. Taking an overdose of these
medicines may cause unconsciousness or death. Signs of overdose include convulsions
(seizures), hearing loss, confusion, ringing or buzzing in the ears, severe
drowsiness or tiredness, severe excitement or nervousness, and fast or deep