Sulfadoxine and Pyrimethamine (Systemic)
Brand Names : Fansidar
Before Using This MedicineIn deciding to use a medicine,
the risks of taking the medicine must be weighed against the good it will
do. This is a decision you and your doctor will make. For sulfadoxine and
pyrimethamine combination, the following should be considered:
Allergies - Tell your doctor if you have ever had any unusual or
allergic reaction to sulfa medicines, furosemide (e.g., Lasix) or thiazide
diuretics (water pills), oral antidiabetics (diabetes medicine you take by
mouth), glaucoma medicine you take by mouth (acetazolamide [e.g., Diamox],
dichlorphenamide [e.g., Daranide], methazolamide [e.g., Neptazane]), or pyrimethamine
(e.g., Daraprim). Also tell your health care professional if you are allergic
to any other substances, such as foods, preservatives, or dyes.
Pregnancy - Studies have not been done in pregnant women. However,
use is not recommended during pregnancy. Studies in rats have shown that sulfadoxine
and pyrimethamine combination may cause birth defects and anemia. Also, women
who travel to an area where there is a chance of getting malaria, and who
may be taking sulfadoxine and pyrimethamine combination, should avoid becoming
pregnant.
Breast-feeding - Sulfadoxine and pyrimethamine pass into the breast
milk. This medicine is not recommended for use during breast-feeding. It may
cause liver problems, anemia, and other unwanted effects in nursing babies.
Children - Sulfadoxine and pyrimethamine combination should
not be used in infants up to 2 months of age.
Older adults - Many medicines have not been studied specifically
in older people. Therefore, it may not be known whether they work exactly
the same way they do in younger adults or if they cause different side effects
or problems in older people. There is no specific information comparing use
of sulfadoxine and pyrimethamine combination in the elderly with use in other
age groups.
Other medicines - Although certain medicines should not be used
together at all, in other cases two different medicines may be used together
even if an interaction might occur. In these cases, your doctor may want to
change the dose, or other precautions may be necessary. When you are taking
sulfadoxine and pyrimethamine combination, it is especially important that
your health care professional know if you are taking any of the following:
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Acetaminophen (e.g., Tylenol) (with long-term, high-dose use) or
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Amiodarone (e.g., Cordarone) or
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Anabolic steroids (nandrolone [e.g., Anabolin], oxandrolone [e.g.,
Anavar], oxymetholone [e.g., Anadrol], stanozolol [e.g., Winstrol]) or
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Androgens (male hormones) or
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Carbamazepine (e.g., Tegretol) or
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Carmustine (e.g., BiCNU) or
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Chloroquine (e.g., Aralen) or
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Dantrolene (e.g., Dantrium) or
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Daunorubicin (e.g., Cerubidine) or
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Disulfiram (e.g., Antabuse) or
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Divalproex (e.g., Depakote) or
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Estrogens (female hormones) or
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Etretinate (e.g., Tegison) or
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Gold salts (medicine for arthritis) or
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Hydroxychloroquine (e.g., Plaquenil) or
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Naltrexone (e.g., Trexan) (with long-term, high-dose use) or
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Oral contraceptives (birth control pills) containing estrogen or
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Other anti-infectives by mouth or by injection (medicine for infection)
or
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Phenothiazines (acetophenazine [e.g., Tindal], chlorpromazine [e.g.,
Thorazine], fluphenazine [e.g., Prolixin], mesoridazine [e.g., Serentil],
perphenazine [e.g., Trilafon], prochlorperazine [e.g., Compazine], promazine
[e.g., Sparine], promethazine [e.g., Phenergan], thioridazine [e.g., Mellaril],
trifluoperazine [e.g., Stelazine], triflupromazine [e.g., Vesprin], trimeprazine
[e.g., Temaril]) or
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Phenytoin (e.g., Dilantin) or
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Valproic acid (e.g., Depakene) - Use of sulfadoxine and pyrimethamine
combination with these medicines may increase the chance of side effects affecting
the liver
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Acetohydroxamic acid (e.g., Lithostat) or
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Amphotericin B by injection (e.g., Fungizone) or
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Antineoplastics (cancer medicines) or
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Azathioprine (e.g., Imuran) or
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Chloramphenicol (e.g., Chloromycetin) or
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Colchicine or
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Cyclophosphamide (e.g., Cytoxan) or
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Dapsone or
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Flucytosine (e.g., Ancobon) or
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Furazolidone (e.g., Furoxone) or
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Ganciclovir (e.g., Cytovene) or
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Interferon (e.g., Intron A, Roferon-A) or
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Nitrofurantoin (e.g., Furadantin) or
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Primaquine or
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Procainamide (e.g., Pronestyl) or
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Quinidine (e.g., Quinidex) or
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Quinine or
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Sulfoxone (e.g., Diasone) or
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Vitamin K (e.g., AquaMEPHYTON, Synkayvite) or
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Zidovudine (e.g., AZT, Retrovir) - Use of sulfadoxine and pyrimethamine
combination with these medicines may increase the chance of side effects affecting
the blood
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Antithyroid agents (medicine for overactive thyroid) or
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Mercaptopurine (e.g., Purinethol) or
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Methotrexate (e.g., Mexate) or
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Methyldopa (e.g., Aldomet) or
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Plicamycin (e.g., Mithracin) - Use of sulfadoxine and pyrimethamine
combination with these medicines may increase the chance of side effects affecting
the liver and the blood
Other medical problems - The presence of other medical
problems may affect the use of sulfadoxine and pyrimethamine combination.
Make sure you tell your doctor if you have any other medical problems, especially:
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Anemia or other blood problems - Patients with these problems
may have an increase in side effects involving the blood
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Kidney disease or
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Liver disease - Patients with kidney and/or liver disease may
have an increased chance of side effects
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Porphyria - This medicine may cause an attack of porphyria
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Seizure disorders, such as epilepsy - High doses of this medicine
may increase the chance of convulsions (seizures)
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