Tenecteplase (Systemic)
Brand Names : TNKase, TNK, TNK-tPA, and, TNK-tissue plasminogen activator
Before Receiving This MedicineIn deciding to use a medicine, the risks of using the medicine must be
weighed against the good it will do. This is a decision you and your doctor
will make. For tenecteplase, the following should be considered:
Allergies - Tell your doctor if you have ever had any unusual
or allergic reaction to tenecteplase. Also tell your doctor and pharmacist
if you are allergic to any other substances.
Pregnancy - Tenecteplase has not been studied in pregnant women.
However, studies in rabbits have shown that multiple intravenous administrations
of tenecteplase cause maternal and embryo toxicity, but no fetal abnormalities
have been observed. Tenecteplase does not cause maternal and embryo toxicity
in rabbits after a single intravenous administration. Before taking this medicine,
make sure your doctor knows if you are pregnant or if you have recently had
a baby. The most common adverse effect of tenecteplase therapy is bleeding, and
pregnancy can increase this risk.
Breast-feeding - It is not known whether tenecteplase passes
into breast milk. Although most medicines pass into breast milk in small amounts,
many of them may be used safely while breast-feeding. Mothers who have been
given this medicine and who wish to breast-feed should discuss this with their
doctor.
Children - Children - Studies on this medicine have been
done only in adult patients, and there is no specific information comparing
use of tenecteplase in children with use in other age groups.
Older adults - The need for treatment with tenecteplase may be
increased in elderly patients with blood clots. However, the chance of bleeding
may also be increased. It is especially important that you discuss the use
of this medicine with your doctor.
Other medicines - Although certain medicines should not be used
together at all, in other cases two different medicines may be used together
even if an interaction might occur. In these cases, your doctor may want to
change the dose, or other precautions may be necessary. Before you receive
tenecteplase, it is especially important that your doctor know if you are
taking any of the following:
-
Anticoagulants (blood thinners) or
-
Aspirin or
-
Clopidogrel (e.g., Plavix)
-
Dipyridamole (e.g., Persantine) or
-
Heparin or
-
Ticlopidine (e.g., Ticlid) or
-
Warfarin (e.g., Coumadin) - The chance of bleeding may be increased
Other medical problems - Other medical problems or
recent childbirth. The presence of other medical problems or recent delivery
of a child may affect the use of tenecteplase. Make sure you tell your doctor
if you have any other medical problems, especially:
-
Blood disease, bleeding problems, or a history of bleeding in any
part of the body or
-
Brain disease or tumor or
-
Heart or blood vessel disease, including irregular heartbeat or
-
High blood pressure or
-
Liver disease or
-
Stroke - The chance of bleeding may be increased
-
Infection - Chance of spreading the infection into the blood
stream
Also, tell your doctor if you have recently had any of the following conditions:
-
Falls or blow to the body or head or any other injury or
-
Injections into a blood vessel or
-
Placement of any tube into the body or
-
Surgery of any kind, including dental surgery - The chance of
serious bleeding may be increased
If you have recently had a baby, use of this medicine may cause serious
bleeding.
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