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You are here : 3-RX.com > Drugs & Medications > Quick Drug Information (DrugNotes) > Adefovir (Oral)

Adefovir (By Mouth)

Adefovir (a-DEF-o-veer)

Treats chronic (ongoing) hepatitis B. This medicine is an antiviral.

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to adefovir.

How to Use This Medicine:


  • Your doctor will tell you how much of this medicine to take and how often. Do not take more medicine or take it more often than your doctor tells you to.
  • You may take this medicine with or without food.
  • Never share your medicine with anyone.

If a dose is missed:

  • If you miss a dose or forget to take your medicine, take it as soon as you can. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose.
  • Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine:

  • Store the medicine at room temperature in a closed container, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine away from children
Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using other medicines that may harm your kidneys, such as cyclosporine (Sandimmune®, Neoral®), tacrolimus (Prograf®), an antibiotic (such as gentamicin, streptomycin, vancomycin, Garamycin®), or pain or arthritis medicine (such as diclofenac, etodolac, indomethacin, Daypro®, Dolobid®, Feldene®, Indocin®, Relafen®, Voltaren®).
Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, HIV or AIDS, other liver disease such as cirrhosis, or have ever had kidney problems. Make sure your doctor knows if you have had a liver transplant.
  • You may need to have a test for HIV/AIDS before you start using this medicine. Adefovir is related to medicines used to treat AIDS. Using adefovir now may cause AIDS medicines to not work as well if you ever need them. Tell your doctor any time you think you have been exposed to HIV or AIDS.
  • Do not stop using this medicine without asking your doctor, because your hepatitis may get worse. After stopping this medicine your doctor will need to check your progress for at least 12 weeks.
  • Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.
  • This medicine will not keep you from giving hepatitis B to your partner during sex. Make sure you understand and practice safe sex, even if your partner also has hepatitis B. Do not share needles with anyone.
Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Dark-colored urine or pale stools
  • Decrease in how much or how often you urinate
  • Extreme weakness, tiredness, or confusion
  • Lightheadedness or fainting
  • Nausea, vomiting, loss of appetite, pain in your upper stomach
  • Rapid breathing or trouble breathing, or nausea and vomiting
  • Your skin or eyes turn yellow

If you notice these less serious side effects, talk with your doctor:

  • Mild stomach pain
  • Mild weakness
If you notice other side effects that you think are caused by this medicine, tell your doctor.

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