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You are here : 3-RX.com > Drugs & Medications > Quick Drug Information (DrugNotes) > Chlordiazepoxide/Amitriptyline (Oral)

Chlordiazepoxide/Amitriptyline (By Mouth)

Amitriptyline (a-mee-TRIP-ti-leen), Chlordiazepoxide (klor-dye-az-e-POX-ide)

Treats depression that is associated with anxiety.Chlordiazepoxide belongs to a class of drugs called benzodiazepines.Amitriptyline belongs to a class of drugs called tricyclic antidepressants.

Brand Name(s):

Limbitrol DS, Limbitrol
There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have ever had an allergic reaction to this medicine or to any benzodiazepine (such as Xanax®, Klonopin®, Tranxene®, Serax®, Ativan®) or tricyclic antidepressant (such as Elavil®, Sinequan®, Tofranil®). If you have taken a monoamine oxidase (MAO) inhibitor (such as Nardil®, Marplan®, Parnate®) within the past 14 days, You should not use this medicine. You should also not take this medicine if you have just had a heart attack.

How to Use This Medicine:


  • Your doctor will tell you how much medicine to take and how often.
  • This medicine can be habit-forming. You should not use more than the prescribed amount or for a longer time than your doctor has ordered.

If a dose is missed:

  • Take the missed dose as soon as possible.
  • Skip the missed dose if it is almost time for your next regular dose.
  • You should not use two doses at the same time.
How to Store and Dispose of This Medicine:

  • Store at room temperature away from heat, direct light, and moisture.
  • Keep all medicine out of the reach of children.
  • Drink plenty of fluids.
Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Avoid drinking alcoholic beverages.
  • Avoid drugs that can make you sleepy such as sleeping pills, sedatives, muscle relaxants, tranquilizers, or narcotic pain killers.
Warnings While Using This Medicine:

  • Check with your doctor before taking if you have glaucoma, difficulty with urination, seizure disorders, an overactive thyroid, or liver, kidney, or heart disease.
  • If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.
  • This medicine may cause drowsiness. If it does, avoid driving a car or operating machinery.
Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Fast or irregular heartbeat
  • Numbness or tingling in the hands and feet
  • Extreme tiredness, difficulty standing
  • Changes in behavior
  • Muscle rigidity
  • Yellow eyes or skin

If you notice these less serious side effects, talk with your doctor:

  • Constipation
  • Diarrhea
  • Nausea and vomiting
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Difficulty urinating
  • Vision changes such as difficulty focusing
If you notice other side effects that you think are caused by this medicine, tell your doctor.

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