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You are here : 3-RX.com > Drugs & Medications > Quick Drug Information (DrugNotes) > Diphenoxylate/Atropine (Oral)

Diphenoxylate/Atropine (By Mouth)

Atropine (A-troe-peen), Diphenoxylate (dye-fen-OX-i-ilate)

Treats diarrhea.

Brand Name(s):

Lomotil, Vi-Atro, Lomocot, Lonox
There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you ever had an allergic reaction to atropine or diphenoxylate.

How to Use This Medicine:

Liquid, Tablet

  • Your doctor will tell you how much to take and how often.
  • Measure the oral liquid medicine with a marked measuring spoon or medicine cup.
  • Drink plenty of caffeine-free, clear liquids such as ginger ale, tea, water, gelatin, or broth during the first 24 hours.

If a dose is missed:

  • Take the missed dose as soon as possible.
  • Skip the missed dose if it is almost time for your next regular dose.
  • You should not use two doses at the same time.
How to Store and Dispose of This Medicine:

  • Store at room temperature, away from heat, moisture, and direct light. Do not freeze the oral liquid.
  • Keep all medicine out of the reach of children.
Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are taking any drugs that could make you sleepy such as antidepressants, strong pain killers, cold and allergy medicine, or tranquilizers.
  • Tell your doctor if you are also taking an MAO inhibitor such as Marplan®, Parnate®, Nardil®, or Eldepryl®.
Warnings While Using This Medicine:

  • Talk with your doctor before taking if you are pregnant, breastfeeding, or have liver or kidney disease, colitis, or other medical problems.
  • This medicine may cause drowsiness. Be careful if you drive a car or use machinery.
  • You should not use this medicine more often or in larger doses than your doctor ordered.
Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Seizures
  • Severe constipation with bloating
  • Irregular or fast heartbeat
  • Trouble breathing
  • Decreased or no urine for more than 8 hours

If you notice these less serious side effects, talk with your doctor:

  • Drowsiness, dizziness, or restlessness
  • Dry mouth
  • Blurred vision
  • Headache
  • Trouble urinating
If you notice other side effects that you think are caused by this medicine, tell your doctor.


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