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You are here : 3-RX.com > Drugs & Medications > Quick Drug Information (DrugNotes) > Fluorouracil (Topical)

Fluorouracil (On The Skin)

Fluorouracil (flure-oh-YOOR-a-sil)

Treats solar keratoses (red wart-like growth on the skin), skin cancer, and tumors on the face.

Brand Name(s):

Efudex, Carac, Fluoroplex
There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have ever had an allergic reaction to fluorouracil.

How to Use This Medicine:

Cream, Liquid

  • Your doctor will tell you how much medicine to take and how often.
  • Use this medicine only on the skin. Do not get this medicine in your eyes, nose, or mouth.
  • Wear medical gloves when putting this medicine on.
  • Wash the skin to be treated with soap and water before putting this medicine on. Also wash your hands before and after using this medicine.
  • Use enough cream or solution to cover the area of skin you are treating.
  • Do not put a bandage over the area unless your doctor has told you to.
  • You should not use fluorouracil more often or for longer periods than ordered by your doctor.

If a dose is missed:

  • Use your medicine as soon as you remember that you have missed your dose.
  • If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose.
  • Do not put on two doses at one time.
How to Store and Dispose of This Medicine:

  • Keep the medicine at room temperature, away from heat and direct light. Do not freeze.
  • Keep all medicine away from children.
Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not mix fluorouracil with other skin lotions or ointments unless your doctor has told you to.
Warnings While Using This Medicine:

  • If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.
  • Let your doctor know about any other medical problems you have.
  • If your doctor tells you to use a bandage, use a gauze bandage with tape, rather than a plastic bandage that is more likely to cause skin irritation.
  • Avoid being in sunlight while using this medicine.
Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Severe skin rash or itching

If you notice these less serious side effects, talk with your doctor:

  • Mild itching or burning
  • Change in skin color where medicine is put on
  • Pain where medicine is put on
  • Hair loss
  • Scarring, blistering, redness, or peeling of skin
If you notice other side effects that you think are caused by this medicine, tell your doctor.


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