3-rx.comCustomer Support
HomeAbout UsFAQContactHelp
News Center
Health Centers
Medical Encyclopedia
Drugs & Medications
Diseases & Conditions
Medical Symptoms
Med. Tests & Exams
Surgery & Procedures
Injuries & Wounds
Diet & Nutrition
Special Topics

\"$alt_text\"');"); } else { echo"\"$alt_text\""; } ?>

You are here : 3-RX.com > Drugs & Medications > Quick Drug Information (DrugNotes) > Imipenem/Cilastatin (Injection)

Imipenem/Cilastatin (Injection)

Cilastatin (sye-la-STAT-in), Imipenem (i-mi-PEN-em)

Treats infections caused by bacteria. Belongs to a class of drugs called antibiotics.

Brand Name(s):

Primaxin IV, Primaxin IM
There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this medicine if you have had an allergic reaction to imipenem, cilastatin, or medicine that causes numbing such as lidocaine.

How to Use This Medicine:


  • Your doctor will prescribe your exact dose and tell you how often it should be given.
  • An intramuscular (in-tra-MUS-kyoo-ler) or IM injection is a shot given in the muscle of your thigh or buttocks.
  • An intravenous (in-tra-VEEN-us) or IV injection is given through a tube put in one of your veins, usually in your arm, wrist, hand, or sometimes in your chest.
  • A nurse or other caregiver trained to give injections will give your treatment.
  • Sometimes you, a family member, or friend can be taught to give your medicine at home.
  • If you have your treatments at home, you should be given a special container for the used needles. Keep it where children or pets cannot reach it.
  • Use a new needle and syringe each time you inject your medicine.

If a dose is missed:

  • This medicine needs to be given on a regular schedule.
  • If you miss more than one dose, call your doctor for instructions.
How to Store and Dispose of This Medicine:

  • Store the liquid medicine in a refrigerator. Do not freeze. Take it out of the refrigerator an hour before the time for your next dose and let it warm to room temperature in a clean, dry place.
  • Store the dry powder and bottles at room temperature, away from heat, moisture, and direct light.
  • Keep all medicine out of the reach of children.
Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are taking probenecid (Benemid®) or ganciclovir (Cytovene®) before you are treated with imipenem/cilastatin.
Warnings While Using This Medicine:

  • Make sure your doctor knows if you have ever had an allergic reaction, especially to any other antibiotics such as penicillin or cephalosporin (Keflex®, Ceclor®).
  • If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.
  • Make sure your doctor knows if you have kidney disease or a seizure disorder.
  • If this medicine gives you diarrhea, talk to your doctor before taking medicine to stop the diarrhea.
  • If your infection does not get better or if it gets worse while you are using this medicine, tell your doctor.
Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Fast or irregular heartbeat
  • Seizures
  • Severe diarrhea (watery or bloody)
  • Skin rash, hives, or itching
  • Swelling in the face, throat, or lips
  • Swelling, pain, or redness near where your IV needle is placed
  • Urinating less than one cup in a day
  • Wheezing or trouble breathing

If you notice these less serious side effects, talk with your doctor:

  • Mild diarrhea, nausea, or vomiting
  • Pain where your IM shot was given
  • Sore mouth or tongue
  • Vaginal itching or discharge
If you notice other side effects that you think are caused by this medicine, tell your doctor.

\"$alt_text\"');"); } else { echo"\"$alt_text\""; } ?>

Home | About Us | FAQ | Contact | Advertising Policy | Privacy Policy | Bookmark Site