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You are here : 3-RX.com > Drugs & Medications > Quick Drug Information (DrugNotes) > Indomethacin (Oral)

Indomethacin (By Mouth)

Indomethacin (in-doe-METH-a-sin)

Treats pain caused by arthritis, gout, bursitis and other medical problems. Belongs to a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs).

Brand Name(s):

Indocin, Indocin SR
There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to indomethacin, aspirin, or other pain arthritis medicines, such as Voltaren®, Naprosyn® or Aleve®, Motrin®, or Clinoril®. The reaction may have included wheezing or trouble breathing, hives, rash, or swelling in the face.

How to Use This Medicine:

Capsule, Long Acting Capsule, Liquid

  • Your doctor will tell you how much to take and how often.
  • Swallow the extended-release capsule whole. Do not crush, open, or chew.
  • Take your capsule or extended-release capsule medicine with a full glass of water.
  • You may take the capsule or extended-release capsule medicine with food, milk, or antacids (such as Maalox® or Mylanta®) so it does not upset your stomach.
  • Shake the oral liquid well before using.
  • Measure each dose of the oral liquid carefully with a marked measuring spoon.

If a dose is missed:

  • Take the missed dose as soon as possible.
  • If it is almost time for your next regular dose, wait until then to take your medicine and skip the missed dose.
  • You should not use two doses at the same time.
How to Store and Dispose of This Medicine:

  • Store at room temperature, away from heat, moisture, and direct light. Do not freeze the oral liquid.
  • Keep all medicine out of the reach of children.
Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • You should not use this medicine with aspirin or products that contain aspirin, naproxen (Aleve®), or ibuprofen (Advil® or Motrin®).
  • Avoid drinking alcohol while you are taking this medicine.
  • Make sure your doctor knows if you are taking Coumadin® or digoxin (Lanoxin®).
Warnings While Using This Medicine:

  • Talk with your doctor before taking indomethcin if you have heart disease, high blood pressure, liver or kidney disease, blood disorders, or ulcers or other stomach problems.
  • Tell your doctor if you are pregnant or breastfeeding.
  • Ulcers and stomach bleeding are sometimes caused by this type of medicine. These problems can happen without warning signs. You may need to see your doctor for regular check-ups while taking this medicine.
Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Severe rash, hives, or itching
  • Rapid swelling of face or around eyes
  • Chest tightness or trouble breathing
  • Unexplained fever or sore throat or fever
  • Unusual bleeding or bruising
  • Yellowing of skin or eyes
  • Decreased amount of urine
  • Severe stomach pain or bloody vomit
  • Black, tarry or bloody stools
  • Severe headache

If you notice these less serious side effects, talk with your doctor:

  • Nausea
  • Diarrhea or constipation
  • Stomach cramps or discomfort
  • Drowsiness or dizziness
  • Swelling of feet or legs or weight gain
  • Sensitivity of skin to sunlight
If you notice other side effects that you think are caused by this medicine, tell your doctor.


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