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You are here : 3-RX.com > Drugs & Medications > Quick Drug Information (DrugNotes) > Ketoconazole (Oral)

Ketoconazole (By Mouth)

Ketoconazole (kee-toe-KOE-na-zole)

Treats fungal infections in the skin, throat, urinary tract, and lungs. Belongs to a class of drugs called antifungals.

Brand Name(s):

Nizoral
There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have ever had an allergic reaction to ketoconazole, miconazole (Monistat®), or fluconazole (Diflucan®). Ketoconazole should not be used with terfenadine (Seldane®), astemizole (Hismanal®), cisapride (Propulsid®), or triazolam (Halcion®).

How to Use This Medicine:

Tablet

  • Your doctor will tell you how much medicine to take and how often. Do not take more medicine or take it more often than your doctor tells you to.
  • Take your ketoconazole until it is gone or until your doctor tells you to stop. If you stop taking the medicine too soon, your infection may return.
  • To avoid stomach upset, ketoconazole may be taken with food or milk unless your doctor tells you differently.

If a dose is missed:

  • Use your medicine as soon as you remember that you have missed your dose.
  • Skip the missed dose. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose.
  • You should not use two doses at one time.
How to Store and Dispose of This Medicine:

  • Keep your medicine at room temperature, away from heat and direct light. Do not freeze.
  • Keep all medicine away from children.
Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Certain drugs should not be used while using ketoconazole. Using these drugs can cause very serious medical problems, heart problems, or even death.
  • Make sure your doctor knows if you are also using antacids, Tagamet®, Pepcid®, Axid®, Zantac®, or Prilosec®.
  • Also, tell your doctor if you are using cyclosporine (Sandimmune®), digoxin (Lanoxin®), isoniazid (INH®), methylprednisolone, midazolam (Versed®), phenytoin (Dilantin®), rifampin (Rifadin®), tacrolimus (Prograf®), or warfarin (Coumadin®).
  • Your doctor may want to test your blood while you are using this medicine. Be sure to keep all appointments.
Warnings While Using This Medicine:

  • If you are pregnant or breast feeding, talk to your doctor before using this medicine.
  • Before using ketoconazole, tell your doctor if you have stomach disorders, liver disease, or drink alcohol more than once a week.
Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Dark-colored urine
  • Fast or irregular heartbeat
  • Loss of appetite
  • Pale colored stools
  • Severe nausea or vomiting
  • Severe rash, hives, or itching
  • Swelling in face, throat, or lips
  • Unusual fatigue
  • Wheezing or trouble breathing
  • Yellow skin and eyes

If you notice these less serious side effects, talk with your doctor:

  • Mild nausea or vomiting
  • Stomach pain
If you notice other side effects that you think are caused by this medicine, tell your doctor.


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