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You are here : 3-RX.com > Drugs & Medications > Quick Drug Information (DrugNotes) > Promethazine (Injection)

Promethazine (Injection)

Promethazine (proe-METH-a-zeen)

Treats, nausea and vomiting. Also used to treat allergic reactions.

Brand Name(s):

Pentazine, Antinaus 50, Promacot, Prorex, Phenergan
There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to promethazine. You should not use promethazine if you are breastfeeding or if you have asthma, narrow-angle glaucoma, stomach or bladder problems, or an enlarged prostate. This medicine should not be given to children under 2 years old.

How to Use This Medicine:


  • Your doctor will prescribe your exact dose and tell you how often it should be given.
  • An IM injection is a shot given in your muscle (upper arm, thigh, buttocks).
  • An IV infusion is medicine that is put directly into your body through one of your veins.
  • This medicine should be given by a person trained to give IV or IM medicine, such as a nurse. Sometimes you, a family member, or a friend can be taught to give your medicine.

If a dose is missed:

  • Use your medicine as soon as you remember that you have missed your dose.
  • Take the rest of your doses for that day at evenly spaced time intervals.
  • You should not use two doses at the same time.
How to Store and Dispose of This Medicine:

  • Store your medicine at room temperature, away from heat and light. Do not freeze.
  • Keep all medicine out of the reach of children.
Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also taking an MAO inhibitor (Marplan®, Nardil®, Parnate®, Eldepryl®), or other medicines that may make you sleepy such as cold and allergy medicine, narcotic pain-killers, sleeping pills, or tranquilizers.
  • Avoid drinking alcohol while taking promethazine.
Warnings While Using This Medicine:

  • If you are pregnant or breastfeeding, talk to your doctor before using this medicine.
  • Before using this medicine, tell your doctor if you have an overactive thyroid, heart or liver disease, high blood pressure, a seizure disorder (epilepsy), bone marrow disease, or diabetes.
  • Tell your doctor or dentist you are using promethazine before you have any kind of surgery.
  • This medicine may make you drowsy or dizzy. Be careful when driving or using machinery.
  • This medicine may make you more sensitive to sunlight. Use a sunscreen when outdoors. Avoid tanning beds and sunlamps.
Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Fast, slow, or irregular heartbeat
  • Slow or troubled breathing
  • Skin rash, itching, hives
  • Yellowing of skin or eyes
  • Pain, burning, or swelling where the IV or shot was given
  • Blurred vision, ringing in the ears

If you notice these less serious side effects, talk with your doctor:

  • Drowsiness or dizziness
  • Trouble sleeping, restlessness, depression
  • Dry mouth
  • Constipation
If you notice other side effects that you think are caused by this medicine, tell your doctor.

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