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You are here : 3-RX.com > Medical Encyclopedia > Tests and Exams > Metyrapone Test: Results and Values
      Category : Health Centers > Endocrine Disorders

Metyrapone Test

Metyrapone Test | Preparation & Expectations | Results and Values

What do the test results mean?

When results of the metyrapone test are normal:

  • 11-deoxycortisol, which is an enzyme that is made before cortisol, rises to more than 7 micrograms per deciliter of blood (mcg/dl)
  • cortisol is increased to less than 10 mcg/dl
  • the ACTH level rises higher than the level obtained from a baseline ACTH level.
  • Abnormal results may vary as follows:

  • No rise in the ACTH level may mean that the pituitary gland is not working normally. This is called hypopituitarism.
  • A great rise in 11-deoxycortisol is a sign of excessive tissue growth in the adrenal gland. Called adrenal hyperplasia, this condition causes the gland to enlarge.
  • No increase in 11-deoxycortisol may indicate:
  • Cushing's syndrome, which is a disorder caused by an overactive adrenal gland
  • adrenal adenoma, a tumor in the adrenal gland
  • cancer, in particular adrenal or lung cancer

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    Metyrapone Test: Preparation & Expectations


    Author: David T. Moran, MD
    Reviewer: Eileen McLaughlin, RN, BSN
    Date Reviewed: 04/26/00

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