Rapidly Progressive Glomerulonephritis
Alternate Names : RPGN, Crescentic Glomerulonephritis
Rapidly progressive glomerulonephritis (RPGN) is a rapid deterioration in
kidney function over a short time. This condition usually occurs when there is an acute inflammation of the kidneys.
What is going on in the body?
RPGN is linked to an immune reaction against the glomerulus, the filtering unit of the kidney. Antibodies that form against an infection can become trapped in the glomeruli. The resulting inflammation causes protein and blood to be excreted in the urine. The ability of the kidneys to get rid of toxic wastes is impaired.
What are the causes and risks of the disease?
The causes of RPGN include:
systemic lupus erythematosus
(SLE), an autoimmune disorder in which the person produces antibodies against his or her own tissue
infection, such as endocarditis,
an inflammation in the heart, or syphilis
viral infections, such as mumps,
measles, or mononucleosis