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Hepatic vein thrombosis following liver resection

Public Health • • SurgeryJan 31 11

Patients undergoing liver surgery have long been considered to be at low risk of venous thromboembolism. However, pulmonary embolism has recently emerged as an increasingly frequent and potentially fatal complication following liver resections.

A research article published on January 21, 2011 in the World Journal of Gastroenterology addresses this question. The authors shed a new light on this discrepancy by reporting two patients who developed thrombi in their hepatic veins following hepatectomy.

The report indicated that thrombosis may occur in hepatic veins after liver resection as a result of intra- or postoperative local injury. This would explain why pulmonary emboli have been observed in the absence of peripheral deep vein thrombosis. This hazard should be taken into account when performing extensive coagulation of the raw surface of the liver when a major hepatic vein is exposed.

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Genetic clues to compulsive, self-injurious behavior in rare childhood disorder

Children's HealthJan 31 11

Research from the University of California, San Diego School of Medicine provides new clues for the compulsive behavior and cognitive defects associated with a rare childhood neurological disease called Lesch-Nyhan Disease (LND). Two pathways found to be defective in LND are known to be associated with other neurodegenerative disease, such as Alzheimer’s and Parknson’s diseases, suggesting common causes of cognitive and behavioral defects in these neurological disorders.

The research is published on-line today in the PLoS ONE.

“This study is important because it opens completely new and unexpected areas of research into the genetic cause of compulsive and self-injurious behavior in Lesch-Nyhan disease,” said principal investigator Theodore Friedmann, MD, professor of pediatrics at UCSD’s Center for Neural Circuit and Behavior and Rady Children’s Hospital-San Diego, a research and teaching affiliate of the UCSD School of Medicine.

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