Heart disease is the number one killer in the world. Several factors that increase the risk for heart disease have been identified by the American Heart Association. Scientific studies have shown significant risk increases with some factors.
The risk factors that are listed are considered major risk factors and are those that medical research has shown to significantly increase the risk of cardiovascular disease. The more risk factors you have the greater the risk you have of developing heart disease. Some of us are at a much greater risk than others. Each factor itself can increase your risk depending on the amount of control you have over it. An example is your blood pressure or diabetes, both can place you at high risk, but if they are under control your risk becomes less whereas if they are uncontrolled the risk will increase even more.
10 Major Risk Factors for Heart Disease
Some of the factors that place us at a higher risk can be controlled, others cannot be controlled. These are considered to be major risk factors by the American Heart Association:
A team of scientists from Worcester Polytechnic Institute (WPI) and CellThera, a private company located in WPI’s Life Sciences and Bioengineering Center, have regenerated functional muscle tissue in mice, opening the door for a new clinical therapy to treat people who suffer major muscle trauma.
The team used a novel protocol to coax mature human muscle cells into a stem cell-like state and grew those reprogrammed cells on biopolymer microthreads. The threads were placed in a wound created by surgically removing a large section of leg muscle from a mouse. Over time, the threads and cells restored near-normal function to the muscle, as reported in the paper “Restoration of Skeletal Muscle Defects with Adult Human Cells Delivered on Fibrin Microthreads,” published in the current issue of the journal Tissue Engineering. Surprisingly, the microthreads, which were used simply as a scaffold to support the reprogrammed human cells, actually seemed to accelerate the regeneration process by recruiting progenitor mouse muscle cells, suggesting that they alone could become a therapeutic tool for treating major muscle trauma.
“We are pleased with the progress of this work, and frankly we were surprised by the level of muscle regeneration that was achieved,” said Raymond Page, assistant professor of biomedical engineering at WPI, chief scientific officer at CellThera, and corresponding author on the paper.