Amphotericin B Lipid Complex (Systemic)

Brand Names : Abelcet

Before Using This Medicine

In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For amphotericin B lipid complex, the following should be considered:

Allergies - Tell your doctor if you have ever had any unusual or allergic reaction to amphotericin B lipid complex. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy - Amphotericin B lipid complex has not been studied in pregnant women. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding - It is not known whether amphotericin B lipid complex passes into breast milk. However, amphotericin B lipid complex is not recommended during breast-feeding, because it may cause unwanted effects in nursing infants.

Children - This medicine has been tested in children and, in effective doses, has not been shown to cause different side effects or problems than it does in adults.

Older adults - This medicine has been tested in a limited number of patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Other medicines - Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are using amphotericin B lipid complex, it is especially important that your health care professional know if you are taking any of the following:

• Acyclovir by injection (e.g., Zovirax) or
• Aminoglycosides (amikacin [e.g., Amikin], gentamicin [e.g., Garamycin], kanamycin [e.g., Kantrex], neomycin [e.g., Mycifradin], netilmicin [e.g., Netromycin], streptomycin, tobramycin [e.g., Nebcin]) or
• Anticonvulsants (medicine for seizures) or
• Bacitracin by injection or
• Capreomycin (e.g., Capastat) or
• Cidofovir (e.g., Vistide) or
• Ciprofloxacin (e.g., Cipro) or
• Cyclosporine (e.g., Sandimmune) or
• Deferoxamine (e.g., Desferal) or
• Demeclocycline (e.g., Declomycin) or
• Foscarnet (e.g., Foscavir) or
• Gold salts (medicine for arthritis) or
• Inflammation or pain medicine or
• Lithium or
• Oxytetracycline (e.g., Terramycin) or
• Pamidronate (e.g., Aredia) or
• Penicillamine (e.g., Cuprimine, Depen) or
• Pentamidine (e.g., NebuPent, Pentam 300) or
• Polymyxins by injection or
• Rifampin (e.g., Rifadin, Rimactane) or
• Sulfamethoxazole and trimethoprim combination (e.g., Bactrim, Cotrim, Septra, Sulfatrim) or
• Sulfonamides (e.g., sulfadiazine, sulfamethizole [e.g., Thiosulfil Forte], sulfamethoxazole [e.g., Gantanol, Urobak], sulfisoxazole [e.g., Gantrisin]) or
• Tacrolimus (e.g., Prograf) or
• Tetracycline (e.g., Achromycin, Sumycin) or
• Tiopronin (e.g., Thiola) or
• Vancomycin by injection (e.g., Vancocin) - Use of these medicines with amphotericin B lipid complex may increase the risk of side effects affecting the kidneys

• Corticosteroids (cortisone-like medicine) or
• Corticotropin (ACTH) or
• Digitalis glycosides (heart medicine) - Use of amphotericin B lipid complex with corticosteroids, corticotropin, or digitalis medicines (such as digoxin) may cause changes in the blood that may increase the chance of heart problems

• Antineoplastic agents (cancer medicine) or
• Chloramphenicol (e.g., Chloromycetin) or
• Clozapine (e.g., Clozaril) or
• Colchicine or
• Didanosine (e.g., Videx) or
• Eflornithine (e.g., Ornidyl) or
• Flucytosine (e.g., Ancobon) or
• Ganciclovir (e.g., Cytovene) or
• Interferon (e.g., Intron A, Roferon-A) or
• Uracil mustard or
• X-ray treatment or
• Zidovudine (e.g., AZT, Retrovir) - Use of these medicines or x-ray treatment with amphotericin B lipid complex may increase the risk of side effects affecting the blood, kidneys, and lungs

Other medical problems - The presence of other medical problems may affect the use of amphotericin B lipid complex. Make sure you tell your doctor if you have any other medical problems, especially:

• Blood transfusion - Amphotericin B lipid complex may cause side effects affecting the lungs

• Kidney disease - Amphotericin B lipid complex may make your kidney problems worse