Brand Names : Targretin
Before Using This Medicine
to use a medicine, the risks of using the medicine must be weighed against
the good it will do. This is a decision you and your doctor will make. For
bexarotene, the following should be considered:
Allergies - Tell your doctor if you have ever had any unusual
or allergic reaction to bexarotene or to other retinoids (vitamin A) preparations.
Also tell your health care professional if you are allergic to any other substances,
such as foods, preservatives, or dyes.
Pregnancy - Bexarotene must not be used
during pregnancy because of the possible risks of birth defects to the infant.
In addition, bexarotene must not be used if there is a chance that you may
become pregnant 1 month before treatment, during treatment, and within 1 month
after treatment is ended.
Women who are able to have children must
have a pregnancy test done within 1 week before starting bexarotene, to make
sure they are not pregnant. The pregnancy test must be repeated once a month
during treatment. You must use two effective forms of birth control at the
same time for 1 month before treatment with bexarotene, during treatment,
and for 1 month after treatment is over or abstain from having intercourse.
Before using this medicine, make sure your doctor knows if you are pregnant
or if you may become pregnant.
Male patients with sexual partners who are pregnant, or who could become
pregnant must use condoms during sexual intercourse while using bexarotene
and for at least 1 month after using the last dose.
Breast-feeding - It is not known whether bexarotene is passed
into breast milk. However, bexarotene use is not recommended during breast-feeding,
because it may cause unwanted effects to the nursing baby.
Children - Studies of this medicine have been done only in
adult patients, and there is no specific information comparing the use of
bexarotene in children with use in other age groups.
Older adults - This medicine has been tested in patients 65 years
of age or older and has not been shown to cause different side effects or
problems in older people than it does in younger adults. However, elderly
patients may be more sensitive to the effects of bexarotene.
Other medicines - Although certain medicines should not be used
together at all, in other cases two different medicines may be used together
even if an interaction might occur. In these cases, your doctor may want to
change the dose, or other precautions may be necessary. When you are taking
bexarotene, it is especially important that your health care professionals
know if you are using any of the following:
Insect repellents containing DEET (N,N-diethyl-m-toluamide) (e.g.,
Off Insect repellant) - using the insect repellant while using bexarotene
can cause you to absorb the repellant through your skin and enter your blood
stream in high amounts.
Vitamin A supplements (e.g., Aquasol A) - May increase the chance
of side effects
Other medical problems - The presence of other medical
problems may affect the use of bexarotene. Make sure you tell your doctor
if you have any other medical problems, especially:
Kidney disease - May increase the risk of side effects
Liver disease - Effects of bexarotene may be increased because
of slower removal from the body
Photosensitivity - Bexarotene may cause increased sensitivity
of the skin to sunlight