Clofazimine (Systemic)
Brand Names : Lamprene
Before Using This MedicineIn deciding to use a medicine,
the risks of taking the medicine must be weighed against the good it will
do. This is a decision you and your doctor will make. For clofazimine, the
following should be considered:
Allergies - Tell your doctor if you have ever had any unusual or
allergic reaction to clofazimine. Also tell your health care professional
if you are allergic to any other substances, such as foods, preservatives,
or dyes.
Pregnancy - Clofazimine has not been studied in pregnant women.
Although the skin of babies born to mothers who took clofazimine during pregnancy
was deeply discolored, this medicine has not been shown to cause birth defects
or other problems in humans. A gradual fading of the discoloration may occur
over a period of about a year. Some animal studies have not shown that clofazimine
causes birth defects. However, studies in mice have shown that clofazimine
may cause slow bone formation of the skull and a decrease in successful pregnancies.
Before you take clofazimine, make sure your doctor knows if you are pregnant
or if you may become pregnant.
Breast-feeding - Clofazimine passes into the breast milk. Use is
not recommended in nursing mothers.
Children - Studies on this medicine have been done only in adult
patients, and there is no specific information comparing use of clofazimine
in children with use in other age groups.
Older adults - Many medicines have not been studied specifically
in older people. Therefore, it may not be known whether they work exactly
the same way they do in younger adults or if they cause different side effects
or problems in older people. There is no specific information comparing use
of clofazimine in the elderly with use in other age groups.
Other medicines - Although certain medicines should not be used
together at all, in other cases two different medicines may be used together
even if an interaction might occur. In these cases, your doctor may want to
change the dose, or other precautions may be necessary. Tell your health care
professional if you are taking any other prescription or nonprescription (over-the-counter
[OTC]) medicine.
Other medical problems - The presence of other medical
problems may affect the use of clofazimine. Make sure you tell your doctor
if you have any other medical problems, especially:
-
Liver disease - Clofazimine may on rare occasion cause hepatitis
and liver disease
-
Stomach or intestinal problems, history of - Clofazimine often
causes some stomach upset, but on rare occasion may cause severe, sharp abdominal
pain and burning, which may be a sign of a serious side effect
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