Conjugated Estrogens and Medroxyprogesterone For Ovarian Hormone Therapy (OHT) (Systemic)

Side Effects of This Medicine

Healthy women rarely have severe side effects from taking conjugated estrogens or medroxyprogesterone to replace estrogen.

Check with your doctor as soon as possible if any of the following side effects occur:

More common

Itching of the vagina or genital area; menstrual periods beginning again, including changing menstrual bleeding pattern for up to 6 months (spotting, breakthrough bleeding, prolonged or heavier vaginal bleeding, or vaginal bleeding completely stopping by 10 months); pain during sexual intercourse; thick, white vaginal discharge

Less common

Blurred vision; breast lumps; chest pain; discharge from breast; dizziness; feeling faint, dizzy, or light-headed; feeling of warmth or heat; flushing or redness of skin, especially on face and neck; headache; heavy nonmenstrual vaginal bleeding; nervousness; pounding in the ears; severe cramping of the uterus; skin rash; slow or fast heartbeat; sweating

Rare

Change in vaginal discharge; pain or feeling of pressure in pelvis; pain or tenderness in stomach, side, or abdomen; yellow eyes or skin

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

More common

Abdominal cramps; back pain; body aches or pain; breast pain or tenderness; congestion; chills; cough; crying; diarrhea; depersonalization; dryness or soreness of throat; dysphoria; enlarged breasts; euphoria; feeling faint, dizzy, or light-headedness; feeling of warmth or heat; fever; flushing or redness of skin, especially on face and neck; general feeling of discomfort or illness; headache, severe and throbbing; hoarseness; increase in amount of clear vaginal discharge; itching; joint pain; lack or loss of strength; loss of appetite; mental depression; muscle aches and pains; nausea; pain; pain or tenderness around eyes and cheekbones; painful menstrual periods; painful or difficult urination; paranoia; passing of gas; pelvic pain; quick to react or overreact emotionally; rapidly changing moods; runny nose; shivering; shortness of breath or troubled breathing; sneezing; sore throat; stuffy nose; stomach discomfort following meals; tender, swollen glands in neck; tightness of chest or wheezing; trouble sleeping; trouble in swallowing; unusual tiredness; voice changes; vomiting

Less common

Acne; bloating or swelling of face, ankles, or feet; cervix disorder; crying; depersonalization; dysphoria; euphoria; increase in sexual desire; leg cramps; mental depression; paranoia; quick to react or overreact emotionally; rapidly changing moods; sleeplessness; tense muscles; trouble sleeping; unable to sleep; unusual weight gain or loss

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.