Didanosine (Systemic)

Brand Names : Videx, ddI

Proper Use of This Medicine

Take this medicine exactly as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Also, do not stop taking this medicine without checking with your doctor first. However, stop taking didanosine and call your doctor right away if you get severe nausea, vomiting, and stomach pain.

Otherwise, keep taking didanosine for the full time of treatment , even if you begin to feel better.

For patients taking didanosine delayed-release capsules :

• Capsules should be swallowed intact.

For patients taking didanosine for oral solution, buffered powder :

• Open the foil packet and pour its contents into approximately 1/2 glass (4 ounces) of water. Do not mix with fruit juice or other acid-containing drinks.
• Stir for approximately 2 to 3 minutes until the powder is dissolved.
• Drink at once.

For patients taking didanosine for oral suspension, pediatric powder :

• Use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

For patients taking didanosine tablets, buffered - chewable and for oral suspension :

• Tablets should be thoroughly chewed or crushed or mixed in at least 1 ounce of water before swallowing. The tablets are hard and some people may find them difficult to chew. If the tablets are mixed in water, stir well until a uniform suspension is formed and take at once. For additional flavoring, mix the prepared suspension with 1 ounce of clear apple juice.
• Two tablets must be taken together by patients over 1 year of age . These tablets contain a special buffer to keep didanosine from being destroyed in the stomach. In order to get the correct amount of buffer, 2 tablets always need to be taken together. Infants from 6 to 12 months of age will get enough buffer from just 1 tablet. For 1-tablet dose, a 1/2 ounce of clear apple juice may be added as a flavor enhancer.

Didanosine should be taken on an empty stomach since food may decrease the absorption in the stomach and keep it from working properly. Didanosine should be taken at least 2 hours before or 2 hours after you eat.

This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses . If you need help in planning the best times to take your medicine, check with your health care professional.

Dosing - The dose of didanosine will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of didanosine. If your dose is different, do not change it unless your doctor tells you to do so.

The number of capsules, tablets or teaspoonfuls of solution or suspension that you take depends on the strength of the medicine.

• For the treatment of advanced HIV infection or AIDS:
  • For oral dosage form (capsules, delayed-release):
    • Adults and teenagers - Dose is based on body weight.
      • For patients weighing less than 60 kilograms (kg) (132 pounds): 250 milligrams (mg) once daily.
      • For patients weighing 60 kg (132 pounds) or more: 400 mg once daily.
    • Children - The oral capsules are usually not used for small children.
  • For oral dosage form (solution, buffered powder):
    • Adults and teenagers - Dose is based on body weight.
      • For patients weighing less than 60 kilograms (kg) (132 pounds): 167 mg every twelve hours.
      • For patients weighing 60 kg (132 pounds) or more: 250 mg every twelve hours.
    • Children - The oral solution is usually not used for small children.
  • For oral dosage form (suspension, pediatric powder):
    • Adults and teenagers - The pediatric oral suspension is usually not used in adults and teenagers.
    • Children - Dose is based on body size and must be determined by your doctor.
  • For oral dosage form (tablets):
    • Adults and teenagers - Dose is based on body weight.
      • For patients weighing less than 60 kg (132 pounds): 125 mg every twelve hours, or 250 mg once daily.
      • For patients weighing 60 kg (132 pounds) or more: 200 mg every twelve hours, or 400 mg once daily.
    • Children - Dose is based on body size and must be determined by your doctor.

Missed dose - If you do miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Only take medicine that your doctor has prescribed specifically for you. Do not share your medicine with others.

Storage - To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.