Brand Names : Antabuse
Before Using This Medicine
In deciding to use a medicine,
the risks of taking the medicine must be weighed against the good it will
do. This is a decision you and your doctor will make. For disulfiram, the
following should be considered:
Allergies - Tell your doctor if you have had any unusual or allergic
reactions to disulfiram, rubber, pesticides, or fungicides.
Diet - In addition to beverages, alcohol is found
in many other products. Reading the list of ingredients on foods and other
products before using them will help you to avoid alcohol. Do not use alcohol-containing
foods such as sauces and vinegars.
Pregnancy - Disulfiram has not been studied in pregnant women.
However, there have been a few reports of birth defects in infants whose mothers
took disulfiram during pregnancy. Before taking this medicine, make sure your
doctor knows if you are pregnant or if you may become pregnant.
Breast-feeding - Disulfiram has not been reported to cause problems
in nursing babies.
Children - Studies on this medicine have been done only in adult
patients, and there is no specific information comparing use of disulfiram
in children with use in other age groups.
Older adults - Many medicines have not been studied specifically
in older people. Therefore, it may not be known whether they work exactly
the same way they do in younger adults or if they cause different side effects
or problems in older people. There is no specific information comparing use
of disulfiram in the elderly with use in other age groups.
Other medicines - Although certain medicines should not be used
together at all, in other cases 2 different medicines may be used together
even if an interaction might occur. In these cases, your doctor may want to
change the dose, or other precautions may be necessary. When you are taking
disulfiram, it is especially important that your health care professional
know if you are taking any of the following:
Anticoagulants (blood thinners) - Taking disulfiram may increase
the effects of anticoagulants, changing the amount you need to take
Ethotoin (e.g., Peganone) or
Mephenytoin (e.g., Mesantoin) or
Phenytoin (e.g., Dilantin) - Taking these medicines with disulfiram
may change the amount of anticonvulsant medicine you need to take
Isoniazid (e.g., INH, Nydrazid) - Disulfiram may increase central
nervous system (CNS) effects, such as dizziness, clumsiness, irritability,
or trouble in sleeping
Ethylene dibromide or organic solvents
(such as chemicals which may contain alcohol, acetaldehyde, paraldehyde,
or other related chemicals used in factories and in hobbies [e.g., paint thinner]) - Make
sure you tell your doctor if you will come in contact with or breathe the
fumes of ethylene dibromide or organic solvents while you are taking disulfiram.
Metronidazole (e.g., Flagyl) or
Paraldehyde (e.g., Paral) - These medicines should not be taken
with or within several days of disulfiram because serious side effects may
Other medical problems - The presence of other medical
problems may affect the use of disulfiram. Make sure you tell your doctor
if you have any other medical problems, especially:
Asthma or other lung disease, severe, or
Diabetes mellitus (sugar diabetes) or
Epilepsy or other seizure disorder or
Heart or blood vessel disease or
Kidney disease or
Liver disease or cirrhosis of the liver or
Underactive thyroid - A disulfiram-alcohol reaction may make
the condition worse
Severe mental illness - Disulfiram may make the condition worse
Skin allergy - Disulfiram may cause an allergic reaction