Ibritumomab Tiuxetan (Systemic)

Brand Names : Zevalin, IDEC-2B8 (ibritumomab tiuxetan), IDEC-Y2B8 (yttrium-90–ibritumomab tiuxetan), IDEC-In2B8 (indium-111–ibritumomab tiuxetan), IDEC-129

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common

Black, tarry stools; bleeding gums; blood in urine or stools; cough or hoarseness; coughing up blood; difficulty in breathing or swallowing; dizziness; fever or chills; headache; increased menstrual flow or vaginal bleeding; large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs; lower back or side pain; noisy breathing; nosebleeds; painful or difficult urination; pale skin; paralysis; pinpoint red spots on skin; prolonged bleeding from cuts; red stools; red or dark brown urine; shortness of breath; sore throat; sores, ulcers, or white spots on lips or in mouth; swollen glands; tightness in chest; troubled breathing with exertion; unusual bleeding or bruising; unusual tiredness or weakness; wheezing

Less common

Bloody nose that does not stop after pinching the nasal alae together and holding them continuously for 5 to 10 minutes; bluish lips or skin; chest pain or discomfort; confusion; diarrhea; fainting; fast heartbeat; hives; itching; lightheadedness; not breathing; pain at site of tumor; puffiness or swelling of the eyelids or around the eyes, face, lips or tongue; rapid, shallow breathing; skin rash; small red or purple spots on skin; unusual vaginal bleeding; vomiting blood or material that looks like coffee grounds

Rare

Agitation; anxiety; back pain; blurred vision; coma; drowsiness; fast, pounding, or irregular heartbeat or pulse; hallucinations; inability to speak; irregular heartbeat; irritability; mood or mental changes; nausea; redness of skin; seizures; severe headache; slurred speech; stiff neck; temporary blindness; vomiting; weakness in arm and/or leg on one side of the body, sudden and severe; welts

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

More common

Abdominal pain or stomach pain; bruising; constipation; difficult or labored breathing; difficulty in moving; faintness or lightheadedness when getting up from a lying or sitting position; fear; feeling of warmth; full or bloated feeling or pressure in the stomach; joint pain; lack or loss of strength; large, flat, blue or purplish patches in the skin; loss of appetite; muscle aching or cramping; muscle pain or stiffness; nervousness; pain; pain in joints; rash; redness of the face, neck, arms and occasionally, upper chest; runny nose; sleeplessness; sneezing; stuffy nose; sudden or increased sweating; swollen joints; swelling of abdominal or stomach area; swelling of hands, ankles, feet, or lower legs; throat irritation; trouble sleeping; unable to sleep; weight loss

Less common

For several months after receiving this therapy, it may still produce some side effects that need attention. During this period of time check with your doctor immediately if you notice any of the following:

Bleeding gums; blurred vision; bone pain; chills; confusion; cough; coughing up blood; difficulty in breathing or swallowing; dizziness; fainting; fast heartbeat; fever; headache, sudden and severe; inability to speak; increased menstrual flow or vaginal bleeding; lightheadedness; lower back or side pain; nosebleeds; painful or difficult urination; pale skin; paralysis; prolonged bleeding from cuts; rapid, shallow breathing; red or dark brown urine; red or black, tarry stools; secondary malignancy; seizures; shallow breathing; shortness of breath; slurred speech; sore throat; temporary blindness; ulcers, sores, or white spots in mouth; unusual bleeding or bruising; unusual tiredness or weakness ; weakness in arm and/or leg on one side of body, sudden and severe

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.